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Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K. Nakamura S, et al. Among authors: nishimura s. Cell Stem Cell. 2014 Apr 3;14(4):535-48. doi: 10.1016/j.stem.2014.01.011. Epub 2014 Feb 13. Cell Stem Cell. 2014. PMID: 24529595 Free article.
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.
Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Takizawa H, et al. Among authors: nishimura s. J Clin Invest. 2010 Jan;120(1):179-90. doi: 10.1172/JCI39503. Epub 2009 Dec 21. J Clin Invest. 2010. PMID: 20038804 Free PMC article.
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K. Takayama N, et al. Among authors: nishimura s, nishimura k. J Exp Med. 2010 Dec 20;207(13):2817-30. doi: 10.1084/jem.20100844. Epub 2010 Nov 22. J Exp Med. 2010. PMID: 21098095 Free PMC article.
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. Nishimura S, et al. Blood. 2012 Feb 23;119(8):e45-56. doi: 10.1182/blood-2011-09-381400. Epub 2011 Nov 16. Blood. 2012. PMID: 22096246 Free PMC article.
3,054 results