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Potent amyloidogenicity and pathogenicity of Aβ43.
Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Saito T, et al. Among authors: nishimura m. Nat Neurosci. 2011 Jul 3;14(8):1023-32. doi: 10.1038/nn.2858. Nat Neurosci. 2011. PMID: 21725313
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M. Nakaya Y, et al. Among authors: nishimura m. J Biol Chem. 2005 May 13;280(19):19070-7. doi: 10.1074/jbc.M501130200. Epub 2005 Mar 10. J Biol Chem. 2005. PMID: 15764596 Free article.
A potential defense mechanism against amyloid deposition in cerebellum.
Shahnur A, Nakano M, Ishihara S, Kakuda N, Miyasaka T, Uchiyama H, Shirai Y, Moniruzzaman M, Saito T, Saido TC, Nishimura M, Funamoto S. Shahnur A, et al. Among authors: nishimura m. Biochem Biophys Res Commun. 2021 Jan 8;535:25-32. doi: 10.1016/j.bbrc.2020.12.036. Epub 2020 Dec 16. Biochem Biophys Res Commun. 2021. PMID: 33340762
Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.
Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, Kimura A, Moteki K, Abe R, Adachi S, Kinoshita S, Yoshizawa-Kumagaye K, Nishio H, Saito T, Saido TC, Yamamoto T, Nishimura M, Taru H, Sobu Y, Ohba H, Nishiyama S, Harada N, Ikeuchi T, Tsukada H, Ouchi Y, Suzuki T. Hata S, et al. Among authors: nishimura m. EMBO Mol Med. 2023 May 8;15(5):e17052. doi: 10.15252/emmm.202217052. Epub 2023 Mar 30. EMBO Mol Med. 2023. PMID: 36994913 Free PMC article.
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Leverenz J, Fagan A, Goate A, Bateman R, Holtzman DM, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: nishimura m. Ann Neurol. 2011 Jun;69(6):1026-31. doi: 10.1002/ana.22343. Ann Neurol. 2011. PMID: 21681798 Free PMC article.
4,455 results