Nimz O - Search Results

1

Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.

Brown AR, Bosies M, Cameron H, Clark J, Cowley A, Craighead M, Elmore MA, Firth A, Goodwin R, Goutcher S, Grant E, Grassie M, Grove SJ, Hamilton NM, Hampson H, Hillier A, Ho KK, Kiczun M, Kingsbury C, Kultgen SG, Littlewood PT, Lusher SJ, Macdonald S, McIntosh L, McIntyre T, Mistry A, Morphy JR, Nimz O, Ohlmeyer M, Pick J, Rankovic Z, Sherborne B, Smith A, Speake M, Spinks G, Thomson F, Watson L, Weston M. Brown AR, et al. Among authors: nimz o. Bioorg Med Chem Lett. 2011 Jan 1;21(1):137-40. doi: 10.1016/j.bmcl.2010.11.054. Epub 2010 Nov 16. Bioorg Med Chem Lett. 2011. PMID: 21129964

2

The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.

Angus D, Bingham M, Buchanan D, Dunbar N, Gibson L, Goodwin R, Haunsø A, Houghton A, Huggett M, Morphy R, Napier S, Nimz O, Passmore J, Walker G. Angus D, et al. Among authors: nimz o. Bioorg Med Chem Lett. 2011 Jan 1;21(1):271-5. doi: 10.1016/j.bmcl.2010.11.021. Epub 2010 Nov 6. Bioorg Med Chem Lett. 2011. PMID: 21112782

3

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.

Ratcliffe P, Abernethy L, Ansari N, Cameron K, Clarkson T, Dempster M, Dunn D, Easson AM, Edwards D, Everett K, Feilden H, Ho KK, Kultgen S, Littlewood P, Maclean J, McArthur D, McGregor D, McLuskey H, Neagu I, Nimz O, Nisbet LA, Ohlmeyer M, Palin R, Pham Q, Rong Y, Roughton A, Sammons M, Swanson R, Tracey H, Walker G. Ratcliffe P, et al. Among authors: nimz o. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4652-7. doi: 10.1016/j.bmcl.2011.01.051. Epub 2011 Jan 26. Bioorg Med Chem Lett. 2011. PMID: 21723725

4

Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.

Lusher SJ, Raaijmakers HC, Vu-Pham D, Dechering K, Lam TW, Brown AR, Hamilton NM, Nimz O, Bosch R, McGuire R, Oubrie A, de Vlieg J. Lusher SJ, et al. Among authors: nimz o. J Biol Chem. 2011 Oct 7;286(40):35079-86. doi: 10.1074/jbc.M111.273029. Epub 2011 Aug 17. J Biol Chem. 2011. PMID: 21849509 Free PMC article.

5

Identification of potent, soluble, and orally active TRPV1 antagonists.

Ratcliffe P, Maclean J, Abernethy L, Clarkson T, Dempster M, Easson AM, Edwards D, Everett K, Feilden H, Littlewood P, McArthur D, McGregor D, McLuskey H, Nimz O, Nisbet LA, Palin R, Tracey H, Walker G. Ratcliffe P, et al. Among authors: nimz o. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2559-63. doi: 10.1016/j.bmcl.2011.01.112. Epub 2011 Jan 31. Bioorg Med Chem Lett. 2011. PMID: 21435873

6

Design, structure activity relationships and X-Ray co-crystallography of non-steroidal LXR agonists.

Bennett DJ, Carswell EL, Cooke AJ, Edwards AS, Nimz O. Bennett DJ, et al. Among authors: nimz o. Curr Med Chem. 2008;15(2):195-209. doi: 10.2174/092986708783330584. Curr Med Chem. 2008. PMID: 18220775 Review.

7

X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.

Fradera X, Vu D, Nimz O, Skene R, Hosfield D, Wynands R, Cooke AJ, Haunsø A, King A, Bennett DJ, McGuire R, Uitdehaag JC. Fradera X, et al. Among authors: nimz o. J Mol Biol. 2010 May 28;399(1):120-32. doi: 10.1016/j.jmb.2010.04.005. Epub 2010 Apr 9. J Mol Biol. 2010. PMID: 20382159

8

Inclusion complexes of V-amylose with undecanoic acid and dodecanol at atomic resolution: X-ray structures with cycloamylose containing 26 D-glucoses (cyclohexaicosaose) as host.

Nimz O, Gessler K, Usón I, Sheldrick GM, Saenger W. Nimz O, et al. Carbohydr Res. 2004 Jun 1;339(8):1427-37. doi: 10.1016/j.carres.2004.02.030. Carbohydr Res. 2004. PMID: 15178384

9

X-ray structure of the cyclomaltohexaicosaose triiodide inclusion complex provides a model for amylose-iodine at atomic resolution.

Nimz O, Gessler K, Usón I, Laettig S, Welfle H, Sheldrick GM, Saenger W. Nimz O, et al. Carbohydr Res. 2003 Apr 22;338(9):977-86. doi: 10.1016/s0008-6215(03)00016-8. Carbohydr Res. 2003. PMID: 12681922

10

Hydrogen-bond network in cyclodecaamylose hydrate at 20 K; neutron diffraction study of novel structural motifs band-flip and kink in alpha-(1-->4)-D-glucoside oligosaccharides.

Imamura K, Nimz O, Jacob J, Myles D, Mason SA, Kitamura S, Aree T, Saenger W. Imamura K, et al. Among authors: nimz o. Acta Crystallogr B. 2001 Dec;57(Pt 6):833-41. doi: 10.1107/S0108768101014288. Epub 2001 Nov 29. Acta Crystallogr B. 2001. PMID: 11717483

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