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Rational Modification of the Biological Profile of GPCR Ligands through Combination with Other Biologically Active Moieties.
Arch Pharm (Weinheim). 2015 Aug;348(8):531-40. doi: 10.1002/ardp.201500079. Epub 2015 May 4.
Arch Pharm (Weinheim). 2015.
PMID: 25941009
Review.
Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties.
Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M.
Nimczick M, et al.
Bioorg Med Chem. 2014 Aug 1;22(15):3938-46. doi: 10.1016/j.bmc.2014.06.008. Epub 2014 Jun 13.
Bioorg Med Chem. 2014.
PMID: 24984935
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Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.
Huang G, Pemp D, Stadtmüller P, Nimczick M, Heilmann J, Decker M.
Huang G, et al. Among authors: nimczick m.
Bioorg Med Chem Lett. 2014 Sep 1;24(17):4209-14. doi: 10.1016/j.bmcl.2014.07.038. Epub 2014 Jul 19.
Bioorg Med Chem Lett. 2014.
PMID: 25096297
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New approaches in the design and development of cannabinoid receptor ligands: multifunctional and bivalent compounds.
Nimczick M, Decker M.
Nimczick M, et al.
ChemMedChem. 2015 May;10(5):773-86. doi: 10.1002/cmdc.201500041. Epub 2015 Mar 27.
ChemMedChem. 2015.
PMID: 25820617
Review.
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Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.
Darras FH, Pockes S, Huang G, Wehle S, Strasser A, Wittmann HJ, Nimczick M, Sotriffer CA, Decker M.
Darras FH, et al. Among authors: nimczick m.
ACS Chem Neurosci. 2014 Mar 19;5(3):225-42. doi: 10.1021/cn4002126. Epub 2014 Jan 14.
ACS Chem Neurosci. 2014.
PMID: 24422467
Free PMC article.
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Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2 R Ligands To Combat Neurodegenerative Disorders.
Dolles D, Nimczick M, Scheiner M, Ramler J, Stadtmüller P, Sawatzky E, Drakopoulos A, Sotriffer C, Wittmann HJ, Strasser A, Decker M.
Dolles D, et al. Among authors: nimczick m.
ChemMedChem. 2016 Jun 20;11(12):1270-83. doi: 10.1002/cmdc.201500418. Epub 2015 Nov 9.
ChemMedChem. 2016.
PMID: 26548365
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