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An oral antisense oligonucleotide for PCSK9 inhibition.
Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117.
Sci Transl Med. 2021.
PMID: 33980578
Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia.
Sokolov V, Helmlinger G, Nilsson C, Zhudenkov K, Skrtic S, Hamrén B, Peskov K, Hurt-Camejo E, Jansson-Löfmark R.
Sokolov V, et al.
J Lipid Res. 2019 Sep;60(9):1610-1621. doi: 10.1194/jlr.M092486. Epub 2019 Jul 10.
J Lipid Res. 2019.
PMID: 31292220
Free PMC article.
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AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval.
Rekić D, Azarov I, Knöchel J, Sokolov V, Nilsson C, Wernevik L, Han D, Rydén-Bergsten T, Ebrahimi A, Dota C, Carlsson B.
Rekić D, et al.
Br J Clin Pharmacol. 2022 Nov;88(11):4839-4844. doi: 10.1111/bcp.15425. Epub 2022 Jun 10.
Br J Clin Pharmacol. 2022.
PMID: 35653229
Free article.
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A case-study of model-informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II.
Knöchel J, Nilsson C, Carlsson B, Wernevik L, Hofherr A, Gennemark P, Jansson-Löfmark R, Isaksson R, Rydén-Bergsten T, Hamrén B, Rekić D.
Knöchel J, et al.
CPT Pharmacometrics Syst Pharmacol. 2022 Dec;11(12):1569-1577. doi: 10.1002/psp4.12866. Epub 2022 Oct 1.
CPT Pharmacometrics Syst Pharmacol. 2022.
PMID: 36126230
Free PMC article.
Clinical Trial.
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Population pharmacokinetics of a novel PCSK9 antisense oligonucleotide.
Clewe O, Rekić D, Quartino AL, Carlsson B, Higashimori M, Wernevik L, Hofherr A, Rydén-Bergsten T, Nilsson C, Knöchel J.
Clewe O, et al.
Br J Clin Pharmacol. 2024 Mar 19. doi: 10.1111/bcp.16046. Online ahead of print.
Br J Clin Pharmacol. 2024.
PMID: 38504437
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