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Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling.
Hansen S, Zhang Y, Hwang S, Nabhan A, Li W, Fuhrmann J, Kschonsak Y, Zhou L, Nile AH, Gao X, Piskol R, de Sousa E Melo F, de Sauvage FJ, Hannoush RN. Hansen S, et al. Among authors: nile ah. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2207327119. doi: 10.1073/pnas.2207327119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343233 Free PMC article.
Fatty acylation of Wnt proteins.
Nile AH, Hannoush RN. Nile AH, et al. Nat Chem Biol. 2016 Feb;12(2):60-9. doi: 10.1038/nchembio.2005. Nat Chem Biol. 2016. PMID: 26784846
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Kömüves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN. Nile AH, et al. Nat Chem Biol. 2018 Jun;14(6):582-590. doi: 10.1038/s41589-018-0035-2. Epub 2018 Apr 9. Nat Chem Biol. 2018. PMID: 29632413
Fatty acid recognition in the Frizzled receptor family.
Nile AH, Hannoush RN. Nile AH, et al. J Biol Chem. 2019 Jan 11;294(2):726-736. doi: 10.1074/jbc.REV118.005205. Epub 2018 Dec 10. J Biol Chem. 2019. PMID: 30530496 Free PMC article. Review.
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Yun J, Hansen S, Morris O, Madden DT, Libeu CP, Kumar AJ, Wehrfritz C, Nile AH, Zhang Y, Zhou L, Liang Y, Modrusan Z, Chen MB, Overall CC, Garfield D, Campisi J, Schilling B, Hannoush RN, Jasper H. Yun J, et al. Among authors: nile ah. Nat Commun. 2023 Jan 11;14(1):156. doi: 10.1038/s41467-022-35487-9. Nat Commun. 2023. PMID: 36631445 Free PMC article.
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition.
Judge RA, Sridar J, Tunyasuvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q. Judge RA, et al. Among authors: nile ah. Nat Commun. 2022 Sep 20;13(1):5500. doi: 10.1038/s41467-022-33175-2. Nat Commun. 2022. PMID: 36127359 Free PMC article.
26 results