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Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.
Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR 4th, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS. Nicholas DA, et al. Among authors: nikolajczyk bs. Cell Metab. 2019 Sep 3;30(3):447-461.e5. doi: 10.1016/j.cmet.2019.07.004. Epub 2019 Aug 1. Cell Metab. 2019. PMID: 31378464 Free PMC article.
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile.
DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian C, Denis GV, Nikolajczyk BS. DeFuria J, et al. Among authors: nikolajczyk bs. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8. doi: 10.1073/pnas.1215840110. Epub 2013 Mar 11. Proc Natl Acad Sci U S A. 2013. PMID: 23479618 Free PMC article. Clinical Trial.
Lymphocyte roles in metabolic dysfunction: of men and mice.
Ip BC, Hogan AE, Nikolajczyk BS. Ip BC, et al. Among authors: nikolajczyk bs. Trends Endocrinol Metab. 2015 Feb;26(2):91-100. doi: 10.1016/j.tem.2014.12.001. Epub 2015 Jan 5. Trends Endocrinol Metab. 2015. PMID: 25573740 Free PMC article. Review.
Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production.
Ip B, Cilfone NA, Belkina AC, DeFuria J, Jagannathan-Bogdan M, Zhu M, Kuchibhatla R, McDonnell ME, Xiao Q, Kepler TB, Apovian CM, Lauffenburger DA, Nikolajczyk BS. Ip B, et al. Among authors: nikolajczyk bs. Obesity (Silver Spring). 2016 Jan;24(1):102-12. doi: 10.1002/oby.21243. Epub 2015 Nov 18. Obesity (Silver Spring). 2016. PMID: 26576827 Free PMC article.
77 results