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5-HT6 receptor antagonists. Design, synthesis, and structure-activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines.
Gałęzowski M, Fabritius CH, Pesonen U, Salo H, Olszak-Płachta M, Czerwińska K, Adamczyk J, Król M, Prusis P, Sieprawska-Lupa M, Mikulski M, Kuokkanen K, Obuchowicz R, Korjamo T, Jalava N, Nikiforuk A, Nowak M. Gałęzowski M, et al. Among authors: nikiforuk a. Bioorg Med Chem Lett. 2023 Nov 15;96:129497. doi: 10.1016/j.bmcl.2023.129497. Epub 2023 Oct 6. Bioorg Med Chem Lett. 2023. PMID: 37806499
The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
Paluchowska MH, Bugno R, Duszyńska B, Tatarczyńska E, Nikiforuk A, Lenda T, Chojnacka-Wójcik E. Paluchowska MH, et al. Among authors: nikiforuk a. Bioorg Med Chem. 2007 Nov 15;15(22):7116-25. doi: 10.1016/j.bmc.2007.07.029. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17825569
2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
Hogendorf AS, Hogendorf A, Kurczab R, Kalinowska-Tłuścik J, Popik P, Nikiforuk A, Krawczyk M, Satała G, Lenda T, Knutelska J, Bugno R, Staroń J, Pietruś W, Matłoka M, Dubiel K, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Pilarski B, Zajdel P, Bojarski AJ. Hogendorf AS, et al. Among authors: nikiforuk a. Eur J Med Chem. 2019 Oct 1;179:1-15. doi: 10.1016/j.ejmech.2019.06.001. Epub 2019 Jun 5. Eur J Med Chem. 2019. PMID: 31229883
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties.
Zajdel P, Grychowska K, Mogilski S, Kurczab R, Satała G, Bugno R, Kos T, Gołębiowska J, Malikowska-Racia N, Nikiforuk A, Chaumont-Dubel S, Bantreil X, Pawłowski M, Martinez J, Subra G, Lamaty F, Marin P, Bojarski AJ, Popik P. Zajdel P, et al. Among authors: nikiforuk a. J Med Chem. 2021 Sep 23;64(18):13279-13298. doi: 10.1021/acs.jmedchem.1c00224. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34467765 Free PMC article.
7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.
Chłoń-Rzepa G, Zmudzki P, Zajdel P, Bojarski AJ, Duszyńska B, Nikiforuk A, Tatarczyńska E, Pawłowski M. Chłoń-Rzepa G, et al. Among authors: nikiforuk a. Bioorg Med Chem. 2007 Aug 1;15(15):5239-50. doi: 10.1016/j.bmc.2007.05.017. Epub 2007 May 10. Bioorg Med Chem. 2007. PMID: 17517514
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Zajdel P, Kos T, Marciniec K, Satała G, Canale V, Kamiński K, Hołuj M, Lenda T, Koralewski R, Bednarski M, Nowiński L, Wójcikowski J, Daniel WA, Nikiforuk A, Nalepa I, Chmielarz P, Kuśmierczyk J, Bojarski AJ, Popik P. Zajdel P, et al. Among authors: nikiforuk a. Eur J Med Chem. 2018 Feb 10;145:790-804. doi: 10.1016/j.ejmech.2018.01.002. Epub 2018 Jan 3. Eur J Med Chem. 2018. PMID: 29407591
2-Phenyl-1H-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity.
Drop M, Canale V, Chaumont-Dubel S, Kurczab R, Satała G, Bantreil X, Walczak M, Koczurkiewicz-Adamczyk P, Latacz G, Gwizdak A, Krawczyk M, Gołębiowska J, Grychowska K, Bojarski AJ, Nikiforuk A, Subra G, Martinez J, Pawłowski M, Popik P, Marin P, Lamaty F, Zajdel P. Drop M, et al. Among authors: nikiforuk a. ACS Chem Neurosci. 2021 Apr 7;12(7):1228-1240. doi: 10.1021/acschemneuro.1c00061. Epub 2021 Mar 11. ACS Chem Neurosci. 2021. PMID: 33705101 Free PMC article.
107 results