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Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases.
Bootsma S, Dings MPG, Kesselaar J, Helderman RFCPA, van Megesen K, Constantinides A, Moreno LF, Stelloo E, Scutigliani EM, Bokan B, Torang A, van Hooff SR, Zwijnenburg DA, Wouters VM, van de Vlasakker VCJ, Galanos LJK, Nijman LE, Logiantara A, Veenstra VL, Schlingemann S, van Piggelen S, van der Wel N, Krawczyk PM, Platteeuw JJ, Tuynman JB, de Hingh IH, Klomp JPG, Oubrie A, Snaebjornsson P, Medema JP, Oei AL, Kranenburg O, Elbers CC, Lenos KJ, Vermeulen L, Bijlsma MF. Bootsma S, et al. Among authors: nijman le. Cell Rep Med. 2024 Apr 22:101523. doi: 10.1016/j.xcrm.2024.101523. Online ahead of print. Cell Rep Med. 2024. PMID: 38670098 Free article.
Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition.
van Driel MS, Linssen JDG, Flanagan DJ, Vlahov N, Nijman LE, de Groot NE, Elbers CC, Koster J, Sansom OJ, Vermeulen L, van Neerven SM. van Driel MS, et al. Among authors: nijman le. Cell Mol Gastroenterol Hepatol. 2023;16(4):652-655. doi: 10.1016/j.jcmgh.2023.06.008. Epub 2023 Jun 24. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37364735 Free PMC article. No abstract available.
Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer.
Buikhuisen JY, Gomez Barila PM, Cameron K, Suijkerbuijk SJE, Lieftink C, di Franco S, Krotenberg Garcia A, Uceda Castro R, Lenos KJ, Nijman LE, Torang A, Longobardi C, de Jong JH, Dekker D, Stassi G, Vermeulen L, Beijersbergen RL, van Rheenen J, Huveneers S, Medema JP. Buikhuisen JY, et al. Among authors: nijman le. J Exp Clin Cancer Res. 2023 Mar 3;42(1):56. doi: 10.1186/s13046-023-02600-9. J Exp Clin Cancer Res. 2023. PMID: 36869386 Free PMC article.
Intestinal Apc-inactivation induces HSP25 dependency.
van Neerven SM, Smit WL, van Driel MS, Kakkar V, de Groot NE, Nijman LE, Elbers CC, Léveillé N, Heijmans J, Vermeulen L. van Neerven SM, et al. Among authors: nijman le. EMBO Mol Med. 2022 Dec 7;14(12):e16194. doi: 10.15252/emmm.202216194. Epub 2022 Nov 2. EMBO Mol Med. 2022. PMID: 36321561 Free PMC article.
Molecular characterization of colorectal cancer related peritoneal metastatic disease.
Lenos KJ, Bach S, Ferreira Moreno L, Ten Hoorn S, Sluiter NR, Bootsma S, Vieira Braga FA, Nijman LE, van den Bosch T, Miedema DM, van Dijk E, Ylstra B, Kulicke R, Davis FP, Stransky N, Smolen GA, Coebergh van den Braak RRJ, IJzermans JNM, Martens JWM, Hallam S, Beggs AD, Kops GJPL, Lansu N, Bastiaenen VP, Klaver CEL, Lecca MC, El Makrini K, Elbers CC, Dings MPG, van Noesel CJM, Kranenburg O, Medema JP, Koster J, Koens L, Punt CJA, Tanis PJ, de Hingh IH, Bijlsma MF, Tuynman JB, Vermeulen L. Lenos KJ, et al. Among authors: nijman le. Nat Commun. 2022 Aug 4;13(1):4443. doi: 10.1038/s41467-022-32198-z. Nat Commun. 2022. PMID: 35927254 Free PMC article.
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas.
Lodestijn SC, van den Bosch T, Nijman LE, Moreno LF, Schlingemann S, Sheraton VM, van Neerven SM, Koning JJ, Vieira Braga FA, Paauw NJ, Lecca MC, Lenos KJ, Morrissey E, Miedema DM, Winton DJ, Bijlsma MF, Vermeulen L. Lodestijn SC, et al. Among authors: nijman le. Cell Stem Cell. 2021 Nov 4;28(11):2009-2019.e4. doi: 10.1016/j.stem.2021.07.004. Epub 2021 Aug 5. Cell Stem Cell. 2021. PMID: 34358441 Free PMC article.
Apc-mutant cells act as supercompetitors in intestinal tumour initiation.
van Neerven SM, de Groot NE, Nijman LE, Scicluna BP, van Driel MS, Lecca MC, Warmerdam DO, Kakkar V, Moreno LF, Vieira Braga FA, Sanches DR, Ramesh P, Ten Hoorn S, Aelvoet AS, van Boxel MF, Koens L, Krawczyk PM, Koster J, Dekker E, Medema JP, Winton DJ, Bijlsma MF, Morrissey E, Léveillé N, Vermeulen L. van Neerven SM, et al. Among authors: nijman le. Nature. 2021 Jun;594(7863):436-441. doi: 10.1038/s41586-021-03558-4. Epub 2021 Jun 2. Nature. 2021. PMID: 34079128
Chromosomal copy number heterogeneity predicts survival rates across cancers.
van Dijk E, van den Bosch T, Lenos KJ, El Makrini K, Nijman LE, van Essen HFB, Lansu N, Boekhout M, Hageman JH, Fitzgerald RC, Punt CJA, Tuynman JB, Snippert HJG, Kops GJPL, Medema JP, Ylstra B, Vermeulen L, Miedema DM. van Dijk E, et al. Among authors: nijman le. Nat Commun. 2021 May 27;12(1):3188. doi: 10.1038/s41467-021-23384-6. Nat Commun. 2021. PMID: 34045449 Free PMC article.
13 results