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IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance.
Cancer Res Commun. 2023 Apr 14;3(4):576-591. doi: 10.1158/2767-9764.CRC-22-0477. eCollection 2023 Apr.
Cancer Res Commun. 2023.
PMID: 37066023
Free PMC article.
Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors.
Deken MA, Niewola-Staszkowska K, Peyruchaud O, Mikulčić N, Antolić M, Shah P, Cheasty A, Tagliavini A, Nizzardo A, Pergher M, Ziviani L, Milleri S, Pickering C, Lahn M, van der Veen L, Di Conza G, Johnson Z.
Deken MA, et al. Among authors: niewola staszkowska k.
Immunooncol Technol. 2023 Apr 8;18:100384. doi: 10.1016/j.iotech.2023.100384. eCollection 2023 Jun.
Immunooncol Technol. 2023.
PMID: 37234285
Free PMC article.
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The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition.
Kalla C, Ott G, Finotello F, Niewola-Staszkowska K, Conza GD, Lahn M, van der Veen L, Schüler J, Falkenstern-Ge R, Kopecka J, Riganti C.
Kalla C, et al. Among authors: niewola staszkowska k.
Transl Oncol. 2024 May;43:101857. doi: 10.1016/j.tranon.2023.101857. Epub 2024 Feb 27.
Transl Oncol. 2024.
PMID: 38412661
Free PMC article.
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Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R.
Riggi M, et al. Among authors: niewola staszkowska k.
Nat Cell Biol. 2018 Sep;20(9):1043-1051. doi: 10.1038/s41556-018-0150-z. Epub 2018 Aug 27.
Nat Cell Biol. 2018.
PMID: 30154550
Free PMC article.
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Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE.
Shekhar-Guturja T, et al. Among authors: niewola staszkowska k.
Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29.
Nat Chem Biol. 2016.
PMID: 27571477
Free PMC article.
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A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.
Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SAL, Baetz K.
Kennedy MA, et al. Among authors: niewola staszkowska k.
Sci Rep. 2016 Jan 13;6:19332. doi: 10.1038/srep19332.
Sci Rep. 2016.
PMID: 26757638
Free PMC article.
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A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.
Kennedy MA, Gable K, Niewola-Staszkowska K, Abreu S, Johnston A, Harris LJ, Reggiori F, Loewith R, Dunn T, Bennett SA, Baetz K.
Kennedy MA, et al. Among authors: niewola staszkowska k.
PLoS Genet. 2014 Jan;10(1):e1004010. doi: 10.1371/journal.pgen.1004010. Epub 2014 Jan 23.
PLoS Genet. 2014.
PMID: 24465216
Free PMC article.
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