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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.
Brouwers O, Niessen PM, Haenen G, Miyata T, Brownlee M, Stehouwer CD, De Mey JG, Schalkwijk CG. Brouwers O, et al. Among authors: niessen pm. Diabetologia. 2010 May;53(5):989-1000. doi: 10.1007/s00125-010-1677-0. Epub 2010 Feb 26. Diabetologia. 2010. PMID: 20186387 Free PMC article.
Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.
Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG. Brouwers O, et al. Among authors: niessen pm. Diabetologia. 2014 Jan;57(1):224-35. doi: 10.1007/s00125-013-3088-5. Epub 2013 Oct 26. Diabetologia. 2014. PMID: 24162587
Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance.
Gaens KH, Goossens GH, Niessen PM, van Greevenbroek MM, van der Kallen CJ, Niessen HW, Rensen SS, Buurman WA, Greve JW, Blaak EE, van Zandvoort MA, Bierhaus A, Stehouwer CD, Schalkwijk CG. Gaens KH, et al. Among authors: niessen pm. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1199-208. doi: 10.1161/ATVBAHA.113.302281. Epub 2014 Apr 10. Arterioscler Thromb Vasc Biol. 2014. PMID: 24723555
A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals.
Linkens AM, Houben AJ, Niessen PM, Wijckmans NE, de Goei EE, Van den Eynde MD, Scheijen JL, van den Waarenburg MP, Mari A, Berendschot TT, Streese L, Hanssen H, van Dongen MC, van Gool CC, Stehouwer CD, Eussen SJ, Schalkwijk CG. Linkens AM, et al. Among authors: niessen pm. JCI Insight. 2022 Mar 22;7(6):e156950. doi: 10.1172/jci.insight.156950. JCI Insight. 2022. PMID: 35133989 Free PMC article. Clinical Trial.
A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial.
Linkens AMA, van Best N, Niessen PM, Wijckmans NEG, de Goei EEC, Scheijen JLJM, van Dongen MCJM, van Gool CCJAW, de Vos WM, Houben AJHM, Stehouwer CDA, Eussen SJMP, Penders J, Schalkwijk CG. Linkens AMA, et al. Among authors: niessen pm. Int J Mol Sci. 2022 May 10;23(10):5328. doi: 10.3390/ijms23105328. Int J Mol Sci. 2022. PMID: 35628138 Free PMC article. Clinical Trial.
17 results