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Angiogenic factors are increased in circulating granulocytes and CD34+ cells of myeloproliferative neoplasms.
Subotički T, Mitrović Ajtić O, Beleslin-Čokić BB, Nienhold R, Diklić M, Djikić D, Leković D, Bulat T, Marković D, Gotić M, Noguchi CT, Schechter AN, Skoda RC, Čokić VP. Subotički T, et al. Among authors: nienhold r. Mol Carcinog. 2017 Feb;56(2):567-579. doi: 10.1002/mc.22517. Epub 2016 Jul 8. Mol Carcinog. 2017. PMID: 27341002 Free PMC article.
Mutational profile of childhood myeloproliferative neoplasms.
Karow A, Nienhold R, Lundberg P, Peroni E, Putti MC, Randi ML, Skoda RC. Karow A, et al. Among authors: nienhold r. Leukemia. 2015 Dec;29(12):2407-9. doi: 10.1038/leu.2015.205. Epub 2015 Jul 30. Leukemia. 2015. PMID: 26223499 No abstract available.
Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis.
Shimizu T, Kubovcakova L, Nienhold R, Zmajkovic J, Meyer SC, Hao-Shen H, Geier F, Dirnhofer S, Guglielmelli P, Vannucchi AM, Feenstra JD, Kralovics R, Orkin SH, Skoda RC. Shimizu T, et al. Among authors: nienhold r. J Exp Med. 2016 Jul 25;213(8):1479-96. doi: 10.1084/jem.20151136. Epub 2016 Jul 11. J Exp Med. 2016. PMID: 27401344 Free PMC article.
Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants.
Pastor V, Hirabayashi S, Karow A, Wehrle J, Kozyra EJ, Nienhold R, Ruzaike G, Lebrecht D, Yoshimi A, Niewisch M, Ripperger T, Göhring G, Baumann I, Schwarz S, Strahm B, Flotho C, Skoda RC, Niemeyer CM, Wlodarski MW. Pastor V, et al. Among authors: nienhold r. Leukemia. 2017 Mar;31(3):759-762. doi: 10.1038/leu.2016.342. Epub 2016 Nov 23. Leukemia. 2017. PMID: 27876779 No abstract available.
A Gain-of-Function Mutation in EPO in Familial Erythrocytosis.
Zmajkovic J, Lundberg P, Nienhold R, Torgersen ML, Sundan A, Waage A, Skoda RC. Zmajkovic J, et al. Among authors: nienhold r. N Engl J Med. 2018 Mar 8;378(10):924-930. doi: 10.1056/NEJMoa1709064. N Engl J Med. 2018. PMID: 29514032 Free article.
The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14.
Drexler B, Passweg JR, Tzankov A, Bigler M, Theocharides AP, Cantoni N, Keller P, Stussi G, Ruefer A, Benz R, Favre G, Lundberg P, Nienhold R, Fuhrer A, Biaggi C, Manz MG, Bargetzi M, Mendez-Ferrer S, Skoda RC; Swiss Group for Clinical Cancer Research (SAKK). Drexler B, et al. Among authors: nienhold r. Haematologica. 2019 Apr;104(4):710-716. doi: 10.3324/haematol.2018.200014. Epub 2018 Nov 8. Haematologica. 2019. PMID: 30409796 Free PMC article. Clinical Trial.
JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms.
Rao TN, Hansen N, Hilfiker J, Rai S, Majewska JM, Leković D, Gezer D, Andina N, Galli S, Cassel T, Geier F, Delezie J, Nienhold R, Hao-Shen H, Beisel C, Di Palma S, Dimeloe S, Trebicka J, Wolf D, Gassmann M, Fan TW, Lane AN, Handschin C, Dirnhofer S, Kröger N, Hess C, Radimerski T, Koschmieder S, Čokić VP, Skoda RC. Rao TN, et al. Among authors: nienhold r. Blood. 2019 Nov 21;134(21):1832-1846. doi: 10.1182/blood.2019000162. Blood. 2019. PMID: 31511238 Free PMC article.
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