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Recent achievements in developing selective Gq inhibitors.
Zhang H, Nielsen AL, Strømgaard K. Zhang H, et al. Among authors: nielsen al. Med Res Rev. 2020 Jan;40(1):135-157. doi: 10.1002/med.21598. Epub 2019 Jun 19. Med Res Rev. 2020. PMID: 31218731 Review.
Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation.
Nielsen AL, Bognar Z, Mothukuri GK, Zarda A, Schuttel M, Merz ML, Ji X, Will E, Chinellato M, Bartling CRO, Stromgaard K, Cendron L, Angelini A, Heinis C. Nielsen AL, et al. Angew Chem Int Ed Engl. 2024 Apr 11:e202400350. doi: 10.1002/anie.202400350. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 38602024
Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase.
Troelsen KS, Bæk M, Nielsen AL, Madsen AS, Rajabi N, Olsen CA. Troelsen KS, et al. Among authors: nielsen al. RSC Chem Biol. 2021 Feb 1;2(2):627-635. doi: 10.1039/d0cb00216j. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458804 Free PMC article.
Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration.
Nielsen AL, Rajabi N, Kudo N, Lundø K, Moreno-Yruela C, Bæk M, Fontenas M, Lucidi A, Madsen AS, Yoshida M, Olsen CA. Nielsen AL, et al. RSC Chem Biol. 2021 Jan 14;2(2):612-626. doi: 10.1039/d0cb00036a. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458803 Free PMC article.
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7.
Bolding JE, Nielsen AL, Jensen I, Hansen TN, Ryberg LA, Jameson ST, Harris P, Peters GHJ, Denu JM, Rogers JM, Olsen CA. Bolding JE, et al. Among authors: nielsen al. Angew Chem Int Ed Engl. 2023 Dec 4;62(49):e202314597. doi: 10.1002/anie.202314597. Epub 2023 Nov 7. Angew Chem Int Ed Engl. 2023. PMID: 37873919
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.
Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD. Shirey RJ, et al. Among authors: nielsen al. Bioorg Med Chem. 2021 Jul 15;42:116246. doi: 10.1016/j.bmc.2021.116246. Epub 2021 Jun 6. Bioorg Med Chem. 2021. PMID: 34130216 Free PMC article.
336 results