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Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
Czestkowski W, Krzemiński Ł, Piotrowicz MC, Mazur M, Pluta E, Andryianau G, Koralewski R, Matyszewski K, Olejniczak S, Kowalski M, Lisiecka K, Kozieł R, Piwowar K, Papiernik D, Nowotny M, Napiórkowska-Gromadzka A, Nowak E, Niedziałek D, Wieczorek G, Siwińska A, Rejczak T, Jędrzejczak K, Mulewski K, Olczak J, Zasłona Z, Gołębiowski A, Drzewicka K, Bartoszewicz A. Czestkowski W, et al. Among authors: niedzialek d. J Med Chem. 2024 Mar 14;67(5):3959-3985. doi: 10.1021/acs.jmedchem.3c02255. Epub 2024 Mar 1. J Med Chem. 2024. PMID: 38427954
Novel orally bioavailable piperidine derivatives as extracellular arginase inhibitors developed by a ring expansion.
Gzik A, Borek B, Chrzanowski J, Jedrzejczak K, Dziegielewski M, Brzezinska J, Nowicka J, Grzybowski MM, Rejczak T, Niedzialek D, Wieczorek G, Olczak J, Golebiowski A, Zaslona Z, Blaszczyk R. Gzik A, et al. Among authors: niedzialek d. Eur J Med Chem. 2024 Jan 15;264:116033. doi: 10.1016/j.ejmech.2023.116033. Epub 2023 Dec 10. Eur J Med Chem. 2024. PMID: 38096651
A model of full-length RAGE in complex with S100B.
Moysa A, Steczkiewicz K, Niedzialek D, Hammerschmid D, Zhukova L, Sobott F, Dadlez M. Moysa A, et al. Among authors: niedzialek d. Structure. 2021 Sep 2;29(9):989-1002.e6. doi: 10.1016/j.str.2021.04.002. Epub 2021 Apr 21. Structure. 2021. PMID: 33887170 Free article.
Structural bases of peptidoglycan recognition by lysostaphin SH3b domain.
Mitkowski P, Jagielska E, Nowak E, Bujnicki JM, Stefaniak F, Niedziałek D, Bochtler M, Sabała I. Mitkowski P, et al. Among authors: niedzialek d. Sci Rep. 2019 Apr 12;9(1):5965. doi: 10.1038/s41598-019-42435-z. Sci Rep. 2019. PMID: 30979923 Free PMC article.
19 results