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Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension.
Taylor S, Isobe S, Cao A, Contrepois K, Benayoun BA, Jiang L, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Moonen JR, Marciano DP, Gu M, Miyagawa K, Hayes B, Sierra RG, Kupitz CJ, Del Rosario PA, Hsi A, Thompson AAR, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M. Taylor S, et al. Among authors: nicolls mr. Am J Respir Crit Care Med. 2022 Oct 15;206(8):1019-1034. doi: 10.1164/rccm.202102-0446OC. Am J Respir Crit Care Med. 2022. PMID: 35696338 Free PMC article.
Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling.
Taraseviciene-Stewart L, Nicolls MR, Kraskauskas D, Scerbavicius R, Burns N, Cool C, Wood K, Parr JE, Boackle SA, Voelkel NF. Taraseviciene-Stewart L, et al. Among authors: nicolls mr. Am J Respir Crit Care Med. 2007 Jun 15;175(12):1280-9. doi: 10.1164/rccm.200608-1189OC. Epub 2007 Apr 5. Am J Respir Crit Care Med. 2007. PMID: 17413127 Free PMC article.
Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension.
Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, Gera L, Patterson AJ, Agrawal R, Rabinovitch M, Ambler K, Long CS, Voelkel NF, Nicolls MR. Tamosiuniene R, et al. Among authors: nicolls mr. Circ Res. 2011 Sep 30;109(8):867-79. doi: 10.1161/CIRCRESAHA.110.236927. Epub 2011 Aug 25. Circ Res. 2011. PMID: 21868697 Free PMC article.
Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth.
Hilgendorff A, Parai K, Ertsey R, Juliana Rey-Parra G, Thébaud B, Tamosiuniene R, Jain N, Navarro EF, Starcher BC, Nicolls MR, Rabinovitch M, Bland RD. Hilgendorff A, et al. Among authors: nicolls mr. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1;303(3):L215-27. doi: 10.1152/ajplung.00405.2011. Epub 2012 Jun 8. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22683569 Free PMC article.
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.
Tian W, Jiang X, Tamosiuniene R, Sung YK, Qian J, Dhillon G, Gera L, Farkas L, Rabinovitch M, Zamanian RT, Inayathullah M, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR. Tian W, et al. Among authors: nicolls mr. Sci Transl Med. 2013 Aug 28;5(200):200ra117. doi: 10.1126/scitranslmed.3006674. Sci Transl Med. 2013. PMID: 23986401 Free PMC article.
152 results