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A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma.
Herrera-Rios D, Li G, Khan D, Tsiampali J, Nickel AC, Aretz P, Hewera M, Suwala AK, Jiang T, Steiger HJ, Kamp MA, Muhammad S, Hänggi D, Maciaczyk J, Zhang W, Kahlert UD. Herrera-Rios D, et al. Among authors: nickel ac. Sci Rep. 2020 Oct 1;10(1):16218. doi: 10.1038/s41598-020-72480-y. Sci Rep. 2020. PMID: 33004830 Free PMC article.
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Koch K, Hartmann R, Tsiampali J, Uhlmann C, Nickel AC, He X, Kamp MA, Sabel M, Barker RA, Steiger HJ, Hänggi D, Willbold D, Maciaczyk J, Kahlert UD. Koch K, et al. Among authors: nickel ac. Cell Death Discov. 2020 Apr 16;6:20. doi: 10.1038/s41420-020-0258-3. eCollection 2020. Cell Death Discov. 2020. PMID: 32337072 Free PMC article.
Rapalink-1 Targets Glioblastoma Stem Cells and Acts Synergistically with Tumor Treating Fields to Reduce Resistance against Temozolomide.
Vargas-Toscano A, Nickel AC, Li G, Kamp MA, Muhammad S, Leprivier G, Fritsche E, Barker RA, Sabel M, Steiger HJ, Zhang W, Hänggi D, Kahlert UD. Vargas-Toscano A, et al. Among authors: nickel ac. Cancers (Basel). 2020 Dec 21;12(12):3859. doi: 10.3390/cancers12123859. Cancers (Basel). 2020. PMID: 33371210 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33563939
Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells.
Li G, Chen TW, Nickel AC, Muhammad S, Steiger HJ, Tzaridis T, Hänggi D, Zeidler R, Zhang W, Kahlert UD. Li G, et al. Among authors: nickel ac. Onco Targets Ther. 2021 Mar 4;14:1707-1718. doi: 10.2147/OTT.S300623. eCollection 2021. Onco Targets Ther. 2021. PMID: 33692626 Free PMC article.
36 results