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Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease.
JCI Insight. 2024 Mar 21;9(9):e176057. doi: 10.1172/jci.insight.176057.
JCI Insight. 2024.
PMID: 38512434
Free article.
Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse.
Duvick L, Southern WM, Benzow K, Burch ZN, Handler HP, Mitchell JS, Kuivinen H, Gadiparthi UK, Yang P, Soles A, Scheeler C, Rainwater O, Serres S, Lind E, Nichols-Meade T, O'Callaghan B, Zoghbi HY, Cvetanovic M, Wheeler VC, Ervasti JM, Koob MD, Orr HT.
Duvick L, et al. Among authors: nichols meade t.
bioRxiv [Preprint]. 2023 Jun 30:2023.02.08.527710. doi: 10.1101/2023.02.08.527710.
bioRxiv. 2023.
PMID: 36798410
Free PMC article.
Preprint.
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Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles.
Handler HP, Duvick L, Mitchell JS, Cvetanovic M, Reighard M, Soles A, Mather KB, Rainwater O, Serres S, Nichols-Meade T, Coffin SL, You Y, Ruis BL, O'Callaghan B, Henzler C, Zoghbi HY, Orr HT.
Handler HP, et al. Among authors: nichols meade t.
Neuron. 2023 Feb 15;111(4):493-507.e6. doi: 10.1016/j.neuron.2022.11.017. Epub 2022 Dec 27.
Neuron. 2023.
PMID: 36577403
Free PMC article.
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Correction to: CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington's disease.
Yu D, Zarate N, White A, Coates D, Tsai W, Nanclares C, Cuccu F, Yue JS, Brown TG, Mansky RH, Jiang K, Kim H, Nichols-Meade T, Larson SN, Gundry K, Zhang Y, Tomas-Zapico C, Lucas JJ, Benneyworth M, Öz G, Cvetanovic M, Araque A, Gomez-Pastor R.
Yu D, et al. Among authors: nichols meade t.
Acta Neuropathol Commun. 2022 Jun 22;10(1):89. doi: 10.1186/s40478-022-01397-6.
Acta Neuropathol Commun. 2022.
PMID: 35733231
Free PMC article.
No abstract available.
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CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington's disease.
Yu D, Zarate N, White A, Coates D, Tsai W, Nanclares C, Cuccu F, Yue JS, Brown TG, Mansky RH, Jiang K, Kim H, Nichols-Meade T, Larson SN, Gundry K, Zhang Y, Tomas-Zapico C, Lucas JJ, Benneyworth M, Öz G, Cvetanovic M, Araque A, Gomez-Pastor R.
Yu D, et al. Among authors: nichols meade t.
Acta Neuropathol Commun. 2022 Jun 3;10(1):83. doi: 10.1186/s40478-022-01379-8.
Acta Neuropathol Commun. 2022.
PMID: 35659303
Free PMC article.
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Long-term behavioral effects observed in mice chronically exposed to static ultra-high magnetic fields.
Tkáč I, Benneyworth MA, Nichols-Meade T, Steuer EL, Larson SN, Metzger GJ, Uğurbil K.
Tkáč I, et al. Among authors: nichols meade t.
Magn Reson Med. 2021 Sep;86(3):1544-1559. doi: 10.1002/mrm.28799. Epub 2021 Apr 6.
Magn Reson Med. 2021.
PMID: 33821502
Free PMC article.
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Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment.
O'Callaghan B, Hofstra B, Handler HP, Kordasiewicz HB, Cole T, Duvick L, Friedrich J, Rainwater O, Yang P, Benneyworth M, Nichols-Meade T, Heal W, Ter Haar R, Henzler C, Orr HT.
O'Callaghan B, et al. Among authors: nichols meade t.
Mol Ther Nucleic Acids. 2020 Sep 4;21:1006-1016. doi: 10.1016/j.omtn.2020.07.030. Epub 2020 Jul 25.
Mol Ther Nucleic Acids. 2020.
PMID: 32818920
Free PMC article.
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Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.
Friedrich J, Kordasiewicz HB, O'Callaghan B, Handler HP, Wagener C, Duvick L, Swayze EE, Rainwater O, Hofstra B, Benneyworth M, Nichols-Meade T, Yang P, Chen Z, Ortiz JP, Clark HB, Öz G, Larson S, Zoghbi HY, Henzler C, Orr HT.
Friedrich J, et al. Among authors: nichols meade t.
JCI Insight. 2018 Nov 2;3(21):e123193. doi: 10.1172/jci.insight.123193.
JCI Insight. 2018.
PMID: 30385727
Free PMC article.
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