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Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Jaye MC, et al. Among authors: nichols ja. J Med Chem. 2005 Aug 25;48(17):5419-22. doi: 10.1021/jm050532w. J Med Chem. 2005. PMID: 16107141
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL. Chao EY, et al. Among authors: nichols ja. J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u. J Med Chem. 2008. PMID: 18800767
Autoimmune Disorders and the Eye.
Thompson L, Patrianakos T, Garcia J, Wadhwa A, Yang E, Thomas C, Schneider R, Stern H, Palma C, Hill K, Barquet V, Anderson-Nelson S, McMahon K, Patel U, Ghadiali Q, Danek D, Larsen B, Wong A, Dawood S, Ludington M, Zhang G, Garakani R, Dwarakanathan S, Simotas A, Sangal K, Phelps P, Ashourian T, Darwish D, Bamba S, Zein M, Nichols J, To J, Sarmiento A, Chaudhary S, Breshears B, Nelson J, Anderson-Nelson S, Giovingo M. Thompson L, et al. Among authors: nichols j. Dis Mon. 2024 Apr 11:101711. doi: 10.1016/j.disamonth.2024.101711. Online ahead of print. Dis Mon. 2024. PMID: 38609837 No abstract available.
1,892 results