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The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi.
Chan LLY, Anderson DE, Cheng HS, Ivan FX, Chen S, Kang AEZ, Foo R, Gamage AM, Tiew PY, Koh MS, Lee KCH, Nichol K, Pathinayake PS, Chan YL, Yeo TW, Oliver BG, Wark PAB, Liu L, Tan NS, Wang LF, Chotirmall SH. Chan LLY, et al. Among authors: nichol k. Nat Commun. 2022 Dec 10;13(1):7635. doi: 10.1038/s41467-022-35253-x. Nat Commun. 2022. PMID: 36496442 Free PMC article.
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations.
Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD, Toussaint M, Walton RP, Finney LJ, Aniscenko J, Zhu J, Trujillo-Torralbo MB, Calderazzo MA, Grainge C, Loo SL, Veerati PC, Pathinayake PS, Nichol KS, Reid AT, James PL, Solari R, Wark PAB, Knight DA, Moffatt MF, Cookson WO, Edwards MR, Mallia P, Bartlett NW, Johnston SL. Singanayagam A, et al. Nat Commun. 2018 Jun 8;9(1):2229. doi: 10.1038/s41467-018-04574-1. Nat Commun. 2018. PMID: 29884817 Free PMC article.
Antiviral immunity is impaired in COPD patients with frequent exacerbations.
Singanayagam A, Loo SL, Calderazzo M, Finney LJ, Trujillo Torralbo MB, Bakhsoliani E, Girkin J, Veerati P, Pathinayake PS, Nichol KS, Reid A, Footitt J, Wark PAB, Grainge CL, Johnston SL, Bartlett NW, Mallia P. Singanayagam A, et al. Am J Physiol Lung Cell Mol Physiol. 2019 Dec 1;317(6):L893-L903. doi: 10.1152/ajplung.00253.2019. Epub 2019 Sep 12. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 31513433 Free PMC article.
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma.
Wark PAB, Pathinayake PS, Kaiko G, Nichol K, Ali A, Chen L, Sutanto EN, Garratt LW, Sohal SS, Lu W, Eapen MS, Oldmeadow C, Bartlett N, Reid A, Veerati P, Hsu AC, Looi K, Iosifidis T, Stick SM, Hansbro PM, Kicic A. Wark PAB, et al. Among authors: nichol k. Respirology. 2021 May;26(5):442-451. doi: 10.1111/resp.14003. Epub 2021 Jan 17. Respirology. 2021. PMID: 33455043 Free PMC article.
Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls.
Hosseini B, Berthon BS, Starkey MR, Collison A, McLoughlin RF, Williams EJ, Nichol K, Wark PA, Jensen ME, Da Silva Sena CR, Baines KJ, Mattes J, Wood LG. Hosseini B, et al. Among authors: nichol k. Front Immunol. 2021 Jun 17;12:664668. doi: 10.3389/fimmu.2021.664668. eCollection 2021. Front Immunol. 2021. PMID: 34220812 Free PMC article.
340 results