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Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model.
Depauw S, Lambert M, Jambon S, Paul A, Peixoto P, Nhili R, Marongiu L, Figeac M, Dassi C, Paul-Constant C, Billoré B, Kumar A, Farahat AA, Ismail MA, Mineva E, Sweat DP, Stephens CE, Boykin DW, Wilson WD, David-Cordonnier MH. Depauw S, et al. Among authors: nhili r. J Med Chem. 2019 Feb 14;62(3):1306-1329. doi: 10.1021/acs.jmedchem.8b01448. Epub 2019 Feb 1. J Med Chem. 2019. PMID: 30645099 Free PMC article.
Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines.
Nhili R, Peixoto P, Depauw S, Flajollet S, Dezitter X, Munde MM, Ismail MA, Kumar A, Farahat AA, Stephens CE, Duterque-Coquillaud M, David Wilson W, Boykin DW, David-Cordonnier MH. Nhili R, et al. Nucleic Acids Res. 2013 Jan 7;41(1):125-38. doi: 10.1093/nar/gks971. Epub 2012 Oct 23. Nucleic Acids Res. 2013. PMID: 23093599 Free PMC article.
Novel diamidino-substituted derivatives of phenyl benzothiazolyl and dibenzothiazolyl furans and thiophenes: synthesis, antiproliferative and DNA binding properties.
Racané L, Tralić-Kulenović V, Kraljević Pavelić S, Ratkaj I, Peixoto P, Nhili R, Depauw S, Hildebrand MP, David-Cordonnier MH, Pavelić K, Karminski-Zamola G. Racané L, et al. Among authors: nhili r. J Med Chem. 2010 Mar 25;53(6):2418-32. doi: 10.1021/jm901441b. J Med Chem. 2010. PMID: 20170096
Water-mediated binding of agents that target the DNA minor groove.
Liu Y, Kumar A, Depauw S, Nhili R, David-Cordonnier MH, Lee MP, Ismail MA, Farahat AA, Say M, Chackal-Catoen S, Batista-Parra A, Neidle S, Boykin DW, Wilson WD. Liu Y, et al. Among authors: nhili r. J Am Chem Soc. 2011 Jul 6;133(26):10171-83. doi: 10.1021/ja202006u. Epub 2011 Jun 15. J Am Chem Soc. 2011. PMID: 21627167 Free PMC article.
Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties.
Aleksić M, Bertoša B, Nhili R, Depauw S, Martin-Kleiner I, David-Cordonnier MH, Tomić S, Kralj M, Karminski-Zamola G. Aleksić M, et al. Among authors: nhili r. Eur J Med Chem. 2014 Jan;71:267-81. doi: 10.1016/j.ejmech.2013.11.010. Epub 2013 Nov 15. Eur J Med Chem. 2014. PMID: 24334150
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