Nguyen LK - Search Results

1

Feedback regulation in cell signalling: Lessons for cancer therapeutics.

Nguyen LK, Kholodenko BN. Nguyen LK, et al. Semin Cell Dev Biol. 2016 Feb;50:85-94. doi: 10.1016/j.semcdb.2015.09.024. Epub 2015 Oct 19. Semin Cell Dev Biol. 2016. PMID: 26481970 Review.

2

Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system.

Nguyen LK, Muñoz-García J, Maccario H, Ciechanover A, Kolch W, Kholodenko BN. Nguyen LK, et al. PLoS Comput Biol. 2011 Dec;7(12):e1002317. doi: 10.1371/journal.pcbi.1002317. Epub 2011 Dec 15. PLoS Comput Biol. 2011. PMID: 22194680 Free PMC article.

3

Signalling by protein phosphatases and drug development: a systems-centred view.

Nguyen LK, Matallanas D, Croucher DR, von Kriegsheim A, Kholodenko BN. Nguyen LK, et al. FEBS J. 2013 Jan;280(2):751-65. doi: 10.1111/j.1742-4658.2012.08522.x. Epub 2012 Mar 14. FEBS J. 2013. PMID: 22340367 Free PMC article. Review.

4

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network.

Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A. Nguyen LK, et al. J Cell Sci. 2013 Mar 15;126(Pt 6):1454-63. doi: 10.1242/jcs.119974. Epub 2013 Feb 6. J Cell Sci. 2013. PMID: 23390316

5

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.

Nguyen LK, Kolch W, Kholodenko BN. Nguyen LK, et al. Cell Commun Signal. 2013 Jul 31;11:52. doi: 10.1186/1478-811X-11-52. Cell Commun Signal. 2013. PMID: 23902637 Free PMC article. Review.

6

Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation.

Nguyen LK, Dobrzyński M, Fey D, Kholodenko BN. Nguyen LK, et al. Front Physiol. 2014 Jan 24;5:4. doi: 10.3389/fphys.2014.00004. eCollection 2014. Front Physiol. 2014. PMID: 24478717 Free PMC article.

7

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.

Romano D, Nguyen LK, Matallanas D, Halasz M, Doherty C, Kholodenko BN, Kolch W. Romano D, et al. Among authors: nguyen lk. Nat Cell Biol. 2014 Jul;16(7):673-84. doi: 10.1038/ncb2986. Epub 2014 Jun 15. Nat Cell Biol. 2014. PMID: 24929361

8

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.

Dobrzyński M, Nguyen LK, Birtwistle MR, von Kriegsheim A, Blanco Fernández A, Cheong A, Kolch W, Kholodenko BN. Dobrzyński M, et al. Among authors: nguyen lk. J R Soc Interface. 2014 Sep 6;11(98):20140383. doi: 10.1098/rsif.2014.0383. J R Soc Interface. 2014. PMID: 24966234 Free PMC article.

9

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T. Kiuchi T, et al. Among authors: nguyen lk. Sci Signal. 2014 Aug 19;7(339):ra78. doi: 10.1126/scisignal.2005157. Sci Signal. 2014. PMID: 25140053

10

Ubiquitin chain specific auto-ubiquitination triggers sustained oscillation, bistable switches and excitable firing.

Nguyen LK, Zhao Q, Varusai TM, Kholodenko BN. Nguyen LK, et al. IET Syst Biol. 2014 Dec;8(6):282-92. doi: 10.1049/iet-syb.2014.0024. IET Syst Biol. 2014. PMID: 25478702 Free PMC article.

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