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Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Lasica AM, Goulas T, Mizgalska D, Zhou X, de Diego I, Ksiazek M, Madej M, Guo Y, Guevara T, Nowak M, Potempa B, Goel A, Sztukowska M, Prabhakar AT, Bzowska M, Widziolek M, Thøgersen IB, Enghild JJ, Simonian M, Kulczyk AW, Nguyen KA, Potempa J, Gomis-Rüth FX. Lasica AM, et al. Among authors: nguyen ka. Sci Rep. 2016 Nov 24;6:37708. doi: 10.1038/srep37708. Sci Rep. 2016. PMID: 27883039 Free PMC article.
The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain.
de Diego I, Ksiazek M, Mizgalska D, Koneru L, Golik P, Szmigielski B, Nowak M, Nowakowska Z, Potempa B, Houston JA, Enghild JJ, Thøgersen IB, Gao J, Kwan AH, Trewhella J, Dubin G, Gomis-Rüth FX, Nguyen KA, Potempa J. de Diego I, et al. Among authors: nguyen ka. Sci Rep. 2016 Mar 23;6:23123. doi: 10.1038/srep23123. Sci Rep. 2016. PMID: 27005013 Free PMC article.
Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases.
Veillard F, Sztukowska M, Mizgalska D, Ksiazek M, Houston J, Potempa B, Enghild JJ, Thogersen IB, Gomis-Rüth FX, Nguyen KA, Potempa J. Veillard F, et al. Among authors: nguyen ka. Biochim Biophys Acta. 2013 Aug;1830(8):4218-28. doi: 10.1016/j.bbagen.2013.04.005. Epub 2013 Apr 10. Biochim Biophys Acta. 2013. PMID: 23583629 Free PMC article.
Purification and characterization of gingipains.
Potempa J, Nguyen KA. Potempa J, et al. Among authors: nguyen ka. Curr Protoc Protein Sci. 2007 Aug;Chapter 21:21.20.1-21.20.27. doi: 10.1002/0471140864.ps2120s49. Curr Protoc Protein Sci. 2007. PMID: 18429320
Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.
Rapala-Kozik M, Bras G, Chruscicka B, Karkowska-Kuleta J, Sroka A, Herwald H, Nguyen KA, Eick S, Potempa J, Kozik A. Rapala-Kozik M, et al. Among authors: nguyen ka. Infect Immun. 2011 Feb;79(2):797-805. doi: 10.1128/IAI.00966-10. Epub 2010 Nov 22. Infect Immun. 2011. PMID: 21098107 Free PMC article.
307 results