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Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission.
Celli R, Wall MJ, Santolini I, Vergassola M, Di Menna L, Mascio G, Cannella M, van Luijtelaar G, Pittaluga A, Ciruela F, Bruno V, Nicoletti F, Ngomba RT. Celli R, et al. Among authors: ngomba rt. Neuropharmacology. 2020 Nov 1;178:108240. doi: 10.1016/j.neuropharm.2020.108240. Epub 2020 Aug 6. Neuropharmacology. 2020. PMID: 32768418
The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia.
Brown J, Iacovelli L, Di Cicco G, Grayson B, Rimmer L, Fletcher J, Neill JC, Wall MJ, Ngomba RT, Harte M. Brown J, et al. Among authors: ngomba rt. Neuropharmacology. 2022 May 1;208:108982. doi: 10.1016/j.neuropharm.2022.108982. Epub 2022 Feb 10. Neuropharmacology. 2022. PMID: 35151699
Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.
Ngomba RT, Santolini I, Biagioni F, Molinaro G, Simonyi A, van Rijn CM, D'Amore V, Mastroiacovo F, Olivieri G, Gradini R, Ferraguti F, Battaglia G, Bruno V, Puliti A, van Luijtelaar G, Nicoletti F. Ngomba RT, et al. Neuropharmacology. 2011 Jun;60(7-8):1281-91. doi: 10.1016/j.neuropharm.2011.01.007. Epub 2011 Jan 26. Neuropharmacology. 2011. PMID: 21277877
Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats.
D'Amore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, van Rijn CM, Vieira E, Stauffer SR, Conn PJ, Bosco P, Nicoletti F, van Luijtelaar G, Ngomba RT. D'Amore V, et al. Among authors: ngomba rt. Neuropharmacology. 2014 Oct;85:91-103. doi: 10.1016/j.neuropharm.2014.05.005. Epub 2014 May 20. Neuropharmacology. 2014. PMID: 24859611 Free PMC article.
The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?
Celli R, Santolini I, Guiducci M, van Luijtelaar G, Parisi P, Striano P, Gradini R, Battaglia G, Ngomba RT, Nicoletti F. Celli R, et al. Among authors: ngomba rt. Curr Neuropharmacol. 2017;15(6):918-925. doi: 10.2174/1570159X15666170309105451. Curr Neuropharmacol. 2017. PMID: 28290248 Free PMC article. Review.
Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.
D'Amore V, Santolini I, van Rijn CM, Biagioni F, Molinaro G, Prete A, Conn PJ, Lindsley CW, Zhou Y, Vinson PN, Rodriguez AL, Jones CK, Stauffer SR, Nicoletti F, van Luijtelaar G, Ngomba RT. D'Amore V, et al. Among authors: ngomba rt. Neuropharmacology. 2013 Mar;66:330-8. doi: 10.1016/j.neuropharm.2012.05.044. Epub 2012 Jun 15. Neuropharmacology. 2013. PMID: 22705340 Free PMC article.
48 results