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Page 1
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress.
Ling NXY, Kaczmarek A, Hoque A, Davie E, Ngoei KRW, Morrison KR, Smiles WJ, Forte GM, Wang T, Lie S, Dite TA, Langendorf CG, Scott JW, Oakhill JS, Petersen J. Ling NXY, et al. Among authors: ngoei krw. Nat Metab. 2020 Jan;2(1):41-49. doi: 10.1038/s42255-019-0157-1. Epub 2020 Jan 20. Nat Metab. 2020. PMID: 31993556 Free PMC article.
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.
Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. Dite TA, et al. Among authors: ngoei krw. Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y. Nat Commun. 2017. PMID: 28924239 Free PMC article.
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.
Pinkosky SL, Scott JW, Desjardins EM, Smith BK, Day EA, Ford RJ, Langendorf CG, Ling NXY, Nero TL, Loh K, Galic S, Hoque A, Smiles WJ, Ngoei KRW, Parker MW, Yan Y, Melcher K, Kemp BE, Oakhill JS, Steinberg GR. Pinkosky SL, et al. Among authors: ngoei krw. Nat Metab. 2020 Sep;2(9):873-881. doi: 10.1038/s42255-020-0245-2. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719536 Free PMC article.
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.
Ovens AJ, Gee YS, Ling NXY, Yu D, Hardee JP, Chung JD, Ngoei KRW, Waters NJ, Hoffman NJ, Scott JW, Loh K, Spengler K, Heller R, Parker MW, Lynch GS, Huang F, Galic S, Kemp BE, Baell JB, Oakhill JS, Langendorf CG. Ovens AJ, et al. Among authors: ngoei krw. Biochem J. 2022 Jun 17;479(11):1181-1204. doi: 10.1042/BCJ20220067. Biochem J. 2022. PMID: 35552369 Free PMC article.
Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.
Ngoei KRW, Langendorf CG, Ling NXY, Hoque A, Varghese S, Camerino MA, Walker SR, Bozikis YE, Dite TA, Ovens AJ, Smiles WJ, Jacobs R, Huang H, Parker MW, Scott JW, Rider MH, Foitzik RC, Kemp BE, Baell JB, Oakhill JS. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. doi: 10.1016/j.chembiol.2018.03.008. Epub 2018 Apr 12. Cell Chem Biol. 2018. PMID: 29657085 Free article.
AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.
Dite TA, Langendorf CG, Hoque A, Galic S, Rebello RJ, Ovens AJ, Lindqvist LM, Ngoei KRW, Ling NXY, Furic L, Kemp BE, Scott JW, Oakhill JS. Dite TA, et al. Among authors: ngoei krw. J Biol Chem. 2018 Jun 8;293(23):8874-8885. doi: 10.1074/jbc.RA118.003547. Epub 2018 Apr 25. J Biol Chem. 2018. PMID: 29695504 Free PMC article.
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.
Langendorf CG, O'Brien MT, Ngoei KRW, McAloon LM, Dhagat U, Hoque A, Ling NXY, Dite TA, Galic S, Loh K, Parker MW, Oakhill JS, Kemp BE, Scott JW. Langendorf CG, et al. Among authors: ngoei krw. J Biol Chem. 2020 Nov 27;295(48):16239-16250. doi: 10.1074/jbc.RA120.013756. Epub 2020 Sep 9. J Biol Chem. 2020. PMID: 32913128 Free PMC article.
An AMPKα2-specific phospho-switch controls lysosomal targeting for activation.
Morrison KR, Smiles WJ, Ling NXY, Hoque A, Shea G, Ngoei KRW, Yu D, Murray-Segal L, Scott JW, Galic S, Kemp BE, Petersen J, Oakhill JS. Morrison KR, et al. Among authors: ngoei krw. Cell Rep. 2022 Feb 15;38(7):110365. doi: 10.1016/j.celrep.2022.110365. Cell Rep. 2022. PMID: 35172150 Free article.
ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways.
Lee HJ, Moon J, Chung I, Chung JH, Park C, Lee JO, Han JA, Kang MJ, Yoo EH, Kwak SY, Jo G, Park W, Park J, Kim KM, Lim S, Ngoei KRW, Ling NXY, Oakhill JS, Galic S, Murray-Segal L, Kemp BE, Mantzoros CS, Krauss RM, Shin MJ, Kim HS. Lee HJ, et al. Among authors: ngoei krw. FASEB J. 2019 Dec;33(12):14825-14840. doi: 10.1096/fj.201901440RR. Epub 2019 Oct 31. FASEB J. 2019. PMID: 31670977
23 results