Newton R - Search Results

1

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R. Holden NS, et al. Among authors: newton r. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11. Proc Natl Acad Sci U S A. 2011. PMID: 22080612 Free PMC article.

2

Inhibitors of p38 mitogen-activated protein kinase: potential as anti-inflammatory agents in asthma?

Newton R, Holden N. Newton R, et al. BioDrugs. 2003;17(2):113-29. doi: 10.2165/00063030-200317020-00004. BioDrugs. 2003. PMID: 12641490 Review.

3

Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89.

Meja KK, Catley MC, Cambridge LM, Barnes PJ, Lum H, Newton R, Giembycz MA. Meja KK, et al. Among authors: newton r. J Pharmacol Exp Ther. 2004 May;309(2):833-44. doi: 10.1124/jpet.103.060020. Epub 2004 Jan 27. J Pharmacol Exp Ther. 2004. PMID: 14747610 Free article.

4

ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK.

Holden NS, Catley MC, Cambridge LM, Barnes PJ, Newton R. Holden NS, et al. Among authors: newton r. Eur J Biochem. 2004 Feb;271(4):785-91. doi: 10.1111/j.1432-1033.2004.03982.x. Eur J Biochem. 2004. PMID: 14764095 Free article.

5

Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.

Clarke DL, Belvisi MG, Catley MC, Yacoub MH, Newton R, Giembycz MA. Clarke DL, et al. Among authors: newton r. Br J Pharmacol. 2004 Apr;141(7):1141-50. doi: 10.1038/sj.bjp.0705716. Epub 2004 Mar 15. Br J Pharmacol. 2004. PMID: 15023863 Free PMC article.

6

E-ring 8-isoprostanes are agonists at EP2- and EP4-prostanoid receptors on human airway smooth muscle cells and regulate the release of colony-stimulating factors by activating cAMP-dependent protein kinase.

Clarke DL, Belvisi MG, Hardaker E, Newton R, Giembycz MA. Clarke DL, et al. Among authors: newton r. Mol Pharmacol. 2005 Feb;67(2):383-93. doi: 10.1124/mol.104.006486. Epub 2004 Nov 4. Mol Pharmacol. 2005. PMID: 15528403

7

Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor.

Clarke DL, Belvisi MG, Smith SJ, Hardaker E, Yacoub MH, Meja KK, Newton R, Slater DM, Giembycz MA. Clarke DL, et al. Among authors: newton r. Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L238-50. doi: 10.1152/ajplung.00313.2004. Am J Physiol Lung Cell Mol Physiol. 2005. PMID: 15640521 Free article.

8

Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells.

Catley MC, Chivers JE, Holden NS, Barnes PJ, Newton R. Catley MC, et al. Among authors: newton r. Br J Pharmacol. 2005 May;145(1):114-22. doi: 10.1038/sj.bjp.0706170. Br J Pharmacol. 2005. PMID: 15723090 Free PMC article.

9

Beyond the dogma: novel beta2-adrenoceptor signalling in the airways.

Giembycz MA, Newton R. Giembycz MA, et al. Among authors: newton r. Eur Respir J. 2006 Jun;27(6):1286-306. doi: 10.1183/09031936.06.00112605. Eur Respir J. 2006. PMID: 16772391 Free article. Review.

10

Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids.

Chivers JE, Gong W, King EM, Seybold J, Mak JC, Donnelly LE, Holden NS, Newton R. Chivers JE, et al. Among authors: newton r. Mol Pharmacol. 2006 Dec;70(6):2084-95. doi: 10.1124/mol.106.025841. Epub 2006 Sep 20. Mol Pharmacol. 2006. PMID: 16988013

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