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Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.
Laws SM, Gaskin S, Woodfield A, Srikanth V, Bruce D, Fraser PE, Porter T, Newsholme P, Wijesekara N, Burnham S, Doré V, Li QX, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL, Martins RN, Verdile G. Laws SM, et al. Among authors: newsholme p. Sci Rep. 2017 Aug 29;7(1):9766. doi: 10.1038/s41598-017-09577-4. Sci Rep. 2017. PMID: 28852028 Free PMC article.
Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels.
Woodfield A, Porter T, Gilani I, Noordin S, Li QX, Collins S, Martins RN, Maruff P, Masters CL, Rowe CC, Villemagne VL, Dore V, Newsholme P, Laws SM, Verdile G; AIBL Research Group. Woodfield A, et al. Among authors: newsholme p. Neurobiol Aging. 2022 Jun;114:38-48. doi: 10.1016/j.neurobiolaging.2022.03.004. Epub 2022 Mar 11. Neurobiol Aging. 2022. PMID: 35381406
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. Masters SL, et al. Among authors: newsholme p. Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12. Nat Immunol. 2010. PMID: 20835230 Free PMC article.
212 results