Newman AH - Search Results

1

Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy.

Zhu R, Sandtner W, Ahiable JEA, Newman AH, Freissmuth M, Sitte HH, Hinterdorfer P. Zhu R, et al. Among authors: newman ah. Front Mol Biosci. 2020 Jun 3;7:99. doi: 10.3389/fmolb.2020.00099. eCollection 2020. Front Mol Biosci. 2020. PMID: 32656227 Free PMC article. Review.

2

Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.

Loland CJ, Desai RI, Zou MF, Cao J, Grundt P, Gerstbrein K, Sitte HH, Newman AH, Katz JL, Gether U. Loland CJ, et al. Among authors: newman ah. Mol Pharmacol. 2008 Mar;73(3):813-23. doi: 10.1124/mol.107.039800. Epub 2007 Oct 31. Mol Pharmacol. 2008. PMID: 17978168

3

Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells.

Wildling L, Rankl C, Haselgrübler T, Gruber HJ, Holy M, Newman AH, Zou MF, Zhu R, Freissmuth M, Sitte HH, Hinterdorfer P. Wildling L, et al. Among authors: newman ah. J Biol Chem. 2012 Jan 2;287(1):105-113. doi: 10.1074/jbc.M111.304873. Epub 2011 Oct 27. J Biol Chem. 2012. PMID: 22033932 Free PMC article.

4

Single molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane.

Anderluh A, Klotzsch E, Reismann AW, Brameshuber M, Kudlacek O, Newman AH, Sitte HH, Schütz GJ. Anderluh A, et al. Among authors: newman ah. J Biol Chem. 2014 Feb 14;289(7):4387-94. doi: 10.1074/jbc.M113.531632. Epub 2014 Jan 6. J Biol Chem. 2014. PMID: 24394416 Free PMC article.

5

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.

Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang YW, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH. Sandtner W, et al. Among authors: newman ah. Mol Pharmacol. 2016 Jan;89(1):165-75. doi: 10.1124/mol.115.101394. Epub 2015 Oct 30. Mol Pharmacol. 2016. PMID: 26519222 Free PMC article.

6

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P. Zhu R, et al. Among authors: newman ah. Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22. Angew Chem Int Ed Engl. 2016. PMID: 26695726 Free PMC article.

7

How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers.

Bhat S, Newman AH, Freissmuth M. Bhat S, et al. Among authors: newman ah. Biochem Soc Trans. 2019 Jun 28;47(3):861-874. doi: 10.1042/BST20180512. Epub 2019 May 7. Biochem Soc Trans. 2019. PMID: 31064865 Free PMC article. Review.

8

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters.

Bhat S, Guthrie DA, Kasture A, El-Kasaby A, Cao J, Bonifazi A, Ku T, Giancola JB, Hummel T, Freissmuth M, Newman AH. Bhat S, et al. Among authors: newman ah. ACS Pharmacol Transl Sci. 2020 Aug 28;4(2):503-516. doi: 10.1021/acsptsci.0c00102. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2020. PMID: 33860180 Free PMC article.

9

Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.

Camacho-Hernandez GA, Casiraghi A, Rudin D, Luethi D, Ku TC, Guthrie DA, Straniero V, Valoti E, Schütz GJ, Sitte HH, Newman AH. Camacho-Hernandez GA, et al. Among authors: newman ah. RSC Med Chem. 2021 Jun 9;12(7):1174-1186. doi: 10.1039/d1md00072a. eCollection 2021 Jul 21. RSC Med Chem. 2021. PMID: 34355183 Free PMC article.

10

Phosphatidylinositol 4,5-bisphosphate (PIP₂) facilitates norepinephrine transporter dimerization and modulates substrate efflux.

Luethi D, Maier J, Rudin D, Szöllősi D, Angenoorth TJF, Stankovic S, Schittmayer M, Burger I, Yang JW, Jaentsch K, Holy M, Das AK, Brameshuber M, Camacho-Hernandez GA, Casiraghi A, Newman AH, Kudlacek O, Birner-Gruenberger R, Stockner T, Schütz GJ, Sitte HH. Luethi D, et al. Among authors: newman ah. Commun Biol. 2022 Nov 17;5(1):1259. doi: 10.1038/s42003-022-04210-1. Commun Biol. 2022. PMID: 36396757 Free PMC article.

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