AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia.
Lopes JA, Garnier NE, Pei Y, Yates JGE, Campbell ESB, Goens MM, Hughes ME, Rghei AD, Stevens BAY, Guilleman MM, Thompson B, Khursigara CM, Susta L, Wootton SK.
Lopes JA, et al.
Gene Ther. 2024 Apr 27. doi: 10.1038/s41434-024-00453-1. Online ahead of print.
Gene Ther. 2024.
PMID: 38678160
Serum concentrations of MEDI3902 were ~10 lower than that of alphaPcrV, but mice treated with this vector showed a greater reduction in bacterial dissemination to the liver, lung, spleen, and blood compared to other AAV-mAbs. These results support further investigation int …
Serum concentrations of MEDI3902 were ~10 lower than that of alphaPcrV, but mice treated with this vector showed a greater reduction in bact …