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Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance.
Smith CD, Lin CT, McMillin SL, Weyrauch LA, Schmidt CA, Smith CA, Kurland IJ, Witczak CA, Neufer PD. Smith CD, et al. Among authors: neufer pd. Am J Physiol Endocrinol Metab. 2021 May 1;320(5):E938-E950. doi: 10.1152/ajpendo.00010.2021. Epub 2021 Apr 5. Am J Physiol Endocrinol Metab. 2021. PMID: 33813880 Free PMC article.
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW 3rd, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD. Anderson EJ, et al. Among authors: neufer pd. J Clin Invest. 2009 Mar;119(3):573-81. doi: 10.1172/JCI37048. Epub 2009 Feb 2. J Clin Invest. 2009. PMID: 19188683 Free PMC article. Clinical Trial.
A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.
Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Ilkayeva O, Muoio DM, Houmard JA. Boyle KE, et al. Among authors: neufer pd. J Clin Endocrinol Metab. 2011 Mar;96(3):775-81. doi: 10.1210/jc.2010-2253. Epub 2010 Dec 29. J Clin Endocrinol Metab. 2011. PMID: 21190973 Free PMC article.
143 results