Nersissian AM - Search Results

1

Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis.

Rodriguez JA, Shaw BF, Durazo A, Sohn SH, Doucette PA, Nersissian AM, Faull KF, Eggers DK, Tiwari A, Hayward LJ, Valentine JS. Rodriguez JA, et al. Among authors: nersissian am. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10516-21. doi: 10.1073/pnas.0502515102. Epub 2005 Jul 14. Proc Natl Acad Sci U S A. 2005. PMID: 16020530 Free PMC article.

2

Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry.

Shaw BF, Durazo A, Nersissian AM, Whitelegge JP, Faull KF, Valentine JS. Shaw BF, et al. Among authors: nersissian am. J Biol Chem. 2006 Jun 30;281(26):18167-76. doi: 10.1074/jbc.M600623200. Epub 2006 Apr 26. J Biol Chem. 2006. PMID: 16644738 Free article.

3

Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein.

Potter SZ, Zhu H, Shaw BF, Rodriguez JA, Doucette PA, Sohn SH, Durazo A, Faull KF, Gralla EB, Nersissian AM, Valentine JS. Potter SZ, et al. Among authors: nersissian am. J Am Chem Soc. 2007 Apr 18;129(15):4575-83. doi: 10.1021/ja066690+. Epub 2007 Mar 24. J Am Chem Soc. 2007. PMID: 17381088

4

Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1.

Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, Whitelegge JP. Shaw BF, et al. Among authors: nersissian am. J Biol Chem. 2008 Mar 28;283(13):8340-50. doi: 10.1074/jbc.M707751200. Epub 2008 Jan 11. J Biol Chem. 2008. PMID: 18192269 Free PMC article.

5

Metal-free superoxide dismutase-1 and three different amyotrophic lateral sclerosis variants share a similar partially unfolded beta-barrel at physiological temperature.

Durazo A, Shaw BF, Chattopadhyay M, Faull KF, Nersissian AM, Valentine JS, Whitelegge JP. Durazo A, et al. Among authors: nersissian am. J Biol Chem. 2009 Dec 4;284(49):34382-9. doi: 10.1074/jbc.M109.052076. Epub 2009 Oct 5. J Biol Chem. 2009. PMID: 19805550 Free PMC article.

6

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.

Lyons TJ, Liu H, Goto JJ, Nersissian A, Roe JA, Graden JA, Café C, Ellerby LM, Bredesen DE, Gralla EB, Valentine JS. Lyons TJ, et al. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12240-4. doi: 10.1073/pnas.93.22.12240. Proc Natl Acad Sci U S A. 1996. PMID: 8901564 Free PMC article.

7

Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant.

Liu H, Zhu H, Eggers DK, Nersissian AM, Faull KF, Goto JJ, Ai J, Sanders-Loehr J, Gralla EB, Valentine JS. Liu H, et al. Among authors: nersissian am. Biochemistry. 2000 Jul 18;39(28):8125-32. doi: 10.1021/bi000846f. Biochemistry. 2000. PMID: 10889018

8

Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis.

Goto JJ, Zhu H, Sanchez RJ, Nersissian A, Gralla EB, Valentine JS, Cabelli DE. Goto JJ, et al. J Biol Chem. 2000 Jan 14;275(2):1007-14. doi: 10.1074/jbc.275.2.1007. J Biol Chem. 2000. PMID: 10625639 Free article.

9

A structure-based mechanism for copper-zinc superoxide dismutase.

Hart PJ, Balbirnie MM, Ogihara NL, Nersissian AM, Weiss MS, Valentine JS, Eisenberg D. Hart PJ, et al. Among authors: nersissian am. Biochemistry. 1999 Feb 16;38(7):2167-78. doi: 10.1021/bi982284u. Biochemistry. 1999. PMID: 10026301

10

Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis.

Hart PJ, Liu H, Pellegrini M, Nersissian AM, Gralla EB, Valentine JS, Eisenberg D. Hart PJ, et al. Among authors: nersissian am. Protein Sci. 1998 Mar;7(3):545-55. doi: 10.1002/pro.5560070302. Protein Sci. 1998. PMID: 9541385 Free PMC article.

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