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Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy.
Calise J, DeBerg H, Garabatos N, Khosa S, Bajzik V, Calderon LB, Aldridge K, Rosasco M, Ferslew BC, Zhu T, Smulders R, Wheatley LM, Laidlaw TM, Qin T, Chichili GR, Adelman DC, Farrington M, Robinson D, Jeong D, Jones SM, Sanda S, Larson D, Kwok WW, Baloh C, Nepom GT, Wambre E; IMPACT. Calise J, et al. Among authors: nepom gt. J Allergy Clin Immunol. 2023 Jul;152(1):155-166.e9. doi: 10.1016/j.jaci.2023.03.020. Epub 2023 Mar 30. J Allergy Clin Immunol. 2023. PMID: 37003475
FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. Among authors: nepom gt. bioRxiv [Preprint]. 2023 Feb 27:2023.02.26.529772. doi: 10.1101/2023.02.26.529772. bioRxiv. 2023. PMID: 36909599 Free PMC article. Updated. Preprint.
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. Among authors: nepom gt. Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9. Nat Commun. 2024. PMID: 38378682 Free PMC article.
HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success.
Kanchan K, Shankar G, Huffaker MF, Bahnson HT, Chinthrajah RS, Sanda S, Manohar M, Ling H, Paschall JE, Toit GD, Ruczinski I, Togias A, Lack G, Nadeau KC, Jones SM, Nepom GT, Mathias RA. Kanchan K, et al. Among authors: nepom gt. Front Immunol. 2022 Nov 18;13:941839. doi: 10.3389/fimmu.2022.941839. eCollection 2022. Front Immunol. 2022. PMID: 36466872 Free PMC article.
293 results