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Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
Chafe SC, Vizeacoumar FS, Venkateswaran G, Nemirovsky O, Awrey S, Brown WS, McDonald PC, Carta F, Metcalfe A, Karasinska JM, Huang L, Muthuswamy SK, Schaeffer DF, Renouf DJ, Supuran CT, Vizeacoumar FJ, Dedhar S. Chafe SC, et al. Among authors: nemirovsky o. Sci Adv. 2021 Aug 27;7(35):eabj0364. doi: 10.1126/sciadv.abj0364. Print 2021 Aug. Sci Adv. 2021. PMID: 34452919 Free PMC article.
Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.
McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, Yapp DT, Li J, Renouf DJ, Stanger BZ, Dedhar S. McDonald PC, et al. Among authors: nemirovsky o. Gastroenterology. 2019 Sep;157(3):823-837. doi: 10.1053/j.gastro.2019.05.004. Epub 2019 May 9. Gastroenterology. 2019. PMID: 31078621 Free article.
Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.
Chafe SC, McDonald PC, Saberi S, Nemirovsky O, Venkateswaran G, Burugu S, Gao D, Delaidelli A, Kyle AH, Baker JHE, Gillespie JA, Bashashati A, Minchinton AI, Zhou Y, Shah SP, Dedhar S. Chafe SC, et al. Among authors: nemirovsky o. Cancer Immunol Res. 2019 Jul;7(7):1064-1078. doi: 10.1158/2326-6066.CIR-18-0657. Epub 2019 May 14. Cancer Immunol Res. 2019. PMID: 31088846
Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX.
Lenferink AEG, McDonald PC, Cantin C, Grothé S, Gosselin M, Baardsnes J, Banville M, Lachance P, Robert A, Cepero-Donates Y, Radinovic S, Salois P, Parat M, Oamari H, Dulude A, Patel M, Lafrance M, Acel A, Bousquet-Gagnon N, L'Abbé D, Pelletier A, Malenfant F, Jaramillo M, O'Connor-Mccourt M, Wu C, Durocher Y, Duchesne M, Gadoury C, Marcil A, Fortin Y, Paul-Roc B, Acchione M, Chafe SC, Nemirovsky O, Lau J, Bénard F, Dedhar S. Lenferink AEG, et al. Among authors: nemirovsky o. MAbs. 2021 Jan-Dec;13(1):1999194. doi: 10.1080/19420862.2021.1999194. MAbs. 2021. PMID: 34806527 Free PMC article.
Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A.
Chu TLH, Connell M, Zhou L, He Z, Won J, Chen H, Rahavi SMR, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielsen TO, Pante N, Maxwell CA. Chu TLH, et al. Among authors: nemirovsky o. Mol Cancer Res. 2018 Jan;16(1):16-31. doi: 10.1158/1541-7786.MCR-17-0417. Epub 2017 Oct 9. Mol Cancer Res. 2018. PMID: 28993511
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
Medyouf H, Gusscott S, Wang H, Tseng JC, Wai C, Nemirovsky O, Trumpp A, Pflumio F, Carboni J, Gottardis M, Pollak M, Kung AL, Aster JC, Holzenberger M, Weng AP. Medyouf H, et al. Among authors: nemirovsky o. J Exp Med. 2011 Aug 29;208(9):1809-22. doi: 10.1084/jem.20110121. Epub 2011 Aug 1. J Exp Med. 2011. PMID: 21807868 Free PMC article.
16 results