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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Zheng J, Haberland V, Baird D, Walker V, Haycock PC, Hurle MR, Gutteridge A, Erola P, Liu Y, Luo S, Robinson J, Richardson TG, Staley JR, Elsworth B, Burgess S, Sun BB, Danesh J, Runz H, Maranville JC, Martin HM, Yarmolinsky J, Laurin C, Holmes MV, Liu JZ, Estrada K, Santos R, McCarthy L, Waterworth D, Nelson MR, Smith GD, Butterworth AS, Hemani G, Scott RA, Gaunt TR. Zheng J, et al. Among authors: nelson mr. Nat Genet. 2020 Oct;52(10):1122-1131. doi: 10.1038/s41588-020-0682-6. Epub 2020 Sep 7. Nat Genet. 2020. PMID: 32895551 Free PMC article.
Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway.
Ehm MG, Aponte JL, Chiano MN, Yerges-Armstrong LM, Johnson T, Barker JN, Cook SF, Gupta A, Hinds DA, Li L, Nelson MR, Simpson MA, Tian C, McCarthy LC, Rajpal DK, Waterworth DM. Ehm MG, et al. Among authors: nelson mr. PLoS One. 2017 Nov 1;12(11):e0186405. doi: 10.1371/journal.pone.0186405. eCollection 2017. PLoS One. 2017. PMID: 29091937 Free PMC article.
The support of human genetic evidence for approved drug indications.
Nelson MR, Tipney H, Painter JL, Shen J, Nicoletti P, Shen Y, Floratos A, Sham PC, Li MJ, Wang J, Cardon LR, Whittaker JC, Sanseau P. Nelson MR, et al. Nat Genet. 2015 Aug;47(8):856-60. doi: 10.1038/ng.3314. Epub 2015 Jun 29. Nat Genet. 2015. PMID: 26121088
The genetics of drug efficacy: opportunities and challenges.
Nelson MR, Johnson T, Warren L, Hughes AR, Chissoe SL, Xu CF, Waterworth DM. Nelson MR, et al. Nat Rev Genet. 2016 Apr;17(4):197-206. doi: 10.1038/nrg.2016.12. Epub 2016 Mar 14. Nat Rev Genet. 2016. PMID: 26972588 Review.
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
Warren LL, Li L, Nelson MR, Ehm MG, Shen J, Fraser DJ, Aponte JL, Nangle KL, Slater AJ, Woollard PM, Hall MD, Topp SD, Yuan X, Cardon LR, Chissoe SL, Mooser V, Morris AD, Palmer CN, Perry JR, Frayling TM, Whittaker JC, Waterworth DM. Warren LL, et al. Among authors: nelson mr. Diabetes. 2012 May;61(5):1297-301. doi: 10.2337/db11-0985. Epub 2012 Mar 8. Diabetes. 2012. PMID: 22403302 Free PMC article.
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.
Nelson MR, Bryc K, King KS, Indap A, Boyko AR, Novembre J, Briley LP, Maruyama Y, Waterworth DM, Waeber G, Vollenweider P, Oksenberg JR, Hauser SL, Stirnadel HA, Kooner JS, Chambers JC, Jones B, Mooser V, Bustamante CD, Roses AD, Burns DK, Ehm MG, Lai EH. Nelson MR, et al. Am J Hum Genet. 2008 Sep;83(3):347-58. doi: 10.1016/j.ajhg.2008.08.005. Epub 2008 Aug 28. Am J Hum Genet. 2008. PMID: 18760391 Free PMC article.
573 results