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Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.
Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, Madison J, Muller M, Arlotta P, Fu Z, Feng G, Eggan K. Nehme R, et al. Cell Rep. 2018 May 22;23(8):2509-2523. doi: 10.1016/j.celrep.2018.04.066. Cell Rep. 2018. PMID: 29791859 Free PMC article.
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.
Madison JM, Zhou F, Nigam A, Hussain A, Barker DD, Nehme R, van der Ven K, Hsu J, Wolf P, Fleishman M, O'Dushlaine C, Rose S, Chambert K, Lau FH, Ahfeldt T, Rueckert EH, Sheridan SD, Fass DM, Nemesh J, Mullen TE, Daheron L, McCarroll S, Sklar P, Perlis RH, Haggarty SJ. Madison JM, et al. Among authors: nehme r. Mol Psychiatry. 2015 Jun;20(6):703-17. doi: 10.1038/mp.2015.7. Epub 2015 Mar 3. Mol Psychiatry. 2015. PMID: 25733313 Free PMC article.
Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development.
McPhie DL, Nehme R, Ravichandran C, Babb SM, Ghosh SD, Staskus A, Kalinowski A, Kaur R, Douvaras P, Du F, Ongur D, Fossati V, Eggan K, Cohen BM. McPhie DL, et al. Among authors: nehme r. Transl Psychiatry. 2018 Oct 23;8(1):230. doi: 10.1038/s41398-018-0284-6. Transl Psychiatry. 2018. PMID: 30352993 Free PMC article.
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.
Nehme R, Pietiläinen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, Bell C, Singh T, Trehan A, Sherwood J, Manning D, Peirent E, Malik R, Guss EJ, Hawes D, Beccard A, Bara AM, Hazelbaker DZ, Zuccaro E, Genovese G, Loboda AA, Neumann A, Lilliehook C, Kuismin O, Hamalainen E, Kurki M, Hultman CM, Kähler AK, Paulo JA, Ganna A, Madison J, Cohen B, McPhie D, Adolfsson R, Perlis R, Dolmetsch R, Farhi S, McCarroll S, Hyman S, Neale B, Barrett LE, Harper W, Palotie A, Daly M, Eggan K. Nehme R, et al. Nat Commun. 2022 Jun 27;13(1):3690. doi: 10.1038/s41467-022-31436-8. Nat Commun. 2022. PMID: 35760976 Free PMC article.
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.
Rapino F, Natoli T, Limone F, O'Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O'Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LL. Rapino F, et al. Among authors: nehme r. Stem Cell Reports. 2023 Jan 10;18(1):237-253. doi: 10.1016/j.stemcr.2022.11.018. Epub 2022 Dec 22. Stem Cell Reports. 2023. PMID: 36563689 Free PMC article.
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.
Limone F, Guerra San Juan I, Mitchell JM, Smith JLM, Raghunathan K, Meyer D, Ghosh SD, Couto A, Klim JR, Joseph BJ, Gold J, Mello CJ, Nemesh J, Smith BM, Verhage M, McCarroll SA, Pietiläinen O, Nehme R, Eggan K. Limone F, et al. Among authors: nehme r. Cell Rep. 2023 Jan 31;42(1):111896. doi: 10.1016/j.celrep.2022.111896. Epub 2023 Jan 2. Cell Rep. 2023. PMID: 36596304 Free PMC article.
118 results