Nefzi A - Search Results

1

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics.

McLaughlin JP, Rayala R, Bunnell AJ, Tantak MP, Eans SO, Nefzi K, Ganno ML, Dooley CT, Nefzi A. McLaughlin JP, et al. Among authors: nefzi a. Int J Mol Sci. 2022 Aug 25;23(17):9623. doi: 10.3390/ijms23179623. Int J Mol Sci. 2022. PMID: 36077029 Free PMC article.

2

Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.

Nefzi A, Dooley C, Ostresh JM, Houghten RA. Nefzi A, et al. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2273-8. doi: 10.1016/s0960-894x(98)00412-0. Bioorg Med Chem Lett. 1998. PMID: 9873527

3

Mixture-based synthetic combinatorial libraries.

Houghten RA, Pinilla C, Appel JR, Blondelle SE, Dooley CT, Eichler J, Nefzi A, Ostresh JM. Houghten RA, et al. Among authors: nefzi a. J Med Chem. 1999 Sep 23;42(19):3743-78. doi: 10.1021/jm990174v. J Med Chem. 1999. PMID: 10508425 Review. No abstract available.

4

Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.

Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA. Nefzi A, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4331-8. doi: 10.1016/j.bmcl.2006.05.053. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750366

5

Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.

Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A, Ostresh JM, Yu Y, Maggiora GM, Medina-Franco JL, Brunner D, Schneider J. Houghten RA, et al. Among authors: nefzi a. J Comb Chem. 2008 Jan-Feb;10(1):3-19. doi: 10.1021/cc7001205. Epub 2007 Dec 8. J Comb Chem. 2008. PMID: 18067268 No abstract available.

6

Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

Yongye AB, Appel JR, Giulianotti MA, Dooley CT, Medina-Franco JL, Nefzi A, Houghten RA, Martínez-Mayorga K. Yongye AB, et al. Among authors: nefzi a. Bioorg Med Chem. 2009 Aug 1;17(15):5583-97. doi: 10.1016/j.bmc.2009.06.026. Epub 2009 Jun 21. Bioorg Med Chem. 2009. PMID: 19576786 Free PMC article.

7

Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.

Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Reilley KJ, et al. Among authors: nefzi a. AAPS J. 2010 Sep;12(3):318-29. doi: 10.1208/s12248-010-9191-3. Epub 2010 Apr 27. AAPS J. 2010. PMID: 20422341 Free PMC article.

8

Integrating computational and mixture-based screening of combinatorial libraries.

Yongye AB, Pinilla C, Medina-Franco JL, Giulianotti MA, Dooley CT, Appel JR, Nefzi A, Scior T, Houghten RA, Martínez-Mayorga K. Yongye AB, et al. Among authors: nefzi a. J Mol Model. 2011 Jun;17(6):1473-82. doi: 10.1007/s00894-010-0850-1. Epub 2010 Sep 21. J Mol Model. 2011. PMID: 20853183

9

Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.

Hammami S, Mighri Z, Dooley CT, Nefzi A. Hammami S, et al. Among authors: nefzi a. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4482-4485. doi: 10.1016/j.bmcl.2014.07.090. Epub 2014 Aug 8. Bioorg Med Chem Lett. 2014. PMID: 25168746

10

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.

Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Eans SO, et al. Among authors: nefzi a. J Med Chem. 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4. J Med Chem. 2015. PMID: 25996309

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