Nefzi A - Search Results

1

Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries.

Perry DL Jr, Roberts BF, Debevec G, Michaels HA, Chakrabarti D, Nefzi A. Perry DL Jr, et al. Among authors: nefzi a. Molecules. 2019 Mar 20;24(6):1100. doi: 10.3390/molecules24061100. Molecules. 2019. PMID: 30897744 Free PMC article.

2

Tethered libraries: solid-phase synthesis of substituted urea-linked bicyclic guanidines.

Acharya AN, Nefzi A, Ostresh JM, Houghten RA. Acharya AN, et al. Among authors: nefzi a. J Comb Chem. 2001 Mar-Apr;3(2):189-95. doi: 10.1021/cc0000803. J Comb Chem. 2001. PMID: 11300860

3

Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: a double diversity for the identification of new antitubercular compounds.

Nefzi A, Appel J, Arutyunyan S, Houghten RA. Nefzi A, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5169-75. doi: 10.1016/j.bmcl.2009.07.010. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19632841

4

Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.

Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Reilley KJ, et al. Among authors: nefzi a. AAPS J. 2010 Sep;12(3):318-29. doi: 10.1208/s12248-010-9191-3. Epub 2010 Apr 27. AAPS J. 2010. PMID: 20422341 Free PMC article.

5

Combinatorial synthesis of oxazol-thiazole bis-heterocyclic compounds.

Murru S, Nefzi A. Murru S, et al. Among authors: nefzi a. ACS Comb Sci. 2014 Jan 13;16(1):39-45. doi: 10.1021/co400133a. Epub 2013 Dec 9. ACS Comb Sci. 2014. PMID: 24295491

6

Synthesis of trifunctional thiazolyl amino acids and their use for the solid-phase synthesis of small molecule compounds and cyclic peptidomimetics.

Michaels HA, Velosa DC, Nefzi A. Michaels HA, et al. Among authors: nefzi a. ACS Comb Sci. 2014 Jan 13;16(1):1-4. doi: 10.1021/co400114u. Epub 2013 Dec 27. ACS Comb Sci. 2014. PMID: 24369098

7

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Houghten RA, et al. Among authors: nefzi a. ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5. ACS Comb Sci. 2016. PMID: 26651386 Free PMC article.

8

Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazines.

Rohde KH, Michaels HA, Nefzi A. Rohde KH, et al. Among authors: nefzi a. Bioorg Med Chem Lett. 2016 May 1;26(9):2206-9. doi: 10.1016/j.bmcl.2016.03.063. Epub 2016 Mar 16. Bioorg Med Chem Lett. 2016. PMID: 27020522

9

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency.

Al-Ali H, Debevec G, Santos RG, Houghten RA, Davis JC, Nefzi A, Lemmon VP, Bixby JL, Giulianotti MA. Al-Ali H, et al. Among authors: nefzi a. ACS Med Chem Lett. 2018 Sep 24;9(10):1057-1062. doi: 10.1021/acsmedchemlett.8b00425. eCollection 2018 Oct 11. ACS Med Chem Lett. 2018. PMID: 30344917 Free PMC article.

10

Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase.

Ortiz MA, Michaels H, Molina B, Toenjes S, Davis J, Marconi GD, Hecht D, Gustafson JL, Piedrafita FJ, Nefzi A. Ortiz MA, et al. Among authors: nefzi a. Bioorg Med Chem Lett. 2020 May 1;30(9):127108. doi: 10.1016/j.bmcl.2020.127108. Epub 2020 Mar 17. Bioorg Med Chem Lett. 2020. PMID: 32192797

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