Neel BG - Search Results

1

Off-target inhibition by active site-targeting SHP2 inhibitors.

Tsutsumi R, Ran H, Neel BG. Tsutsumi R, et al. Among authors: neel bg. FEBS Open Bio. 2018 Aug 1;8(9):1405-1411. doi: 10.1002/2211-5463.12493. eCollection 2018 Sep. FEBS Open Bio. 2018. PMID: 30186742 Free PMC article.

2

SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.

Takahashi A, Tsutsumi R, Kikuchi I, Obuse C, Saito Y, Seidi A, Karisch R, Fernandez M, Cho T, Ohnishi N, Rozenblatt-Rosen O, Meyerson M, Neel BG, Hatakeyama M. Takahashi A, et al. Among authors: neel bg. Mol Cell. 2011 Jul 8;43(1):45-56. doi: 10.1016/j.molcel.2011.05.014. Mol Cell. 2011. PMID: 21726809 Free PMC article.

3

Sticking It to Cancer with Molecular Glue for SHP2.

Ran H, Tsutsumi R, Araki T, Neel BG. Ran H, et al. Among authors: neel bg. Cancer Cell. 2016 Aug 8;30(2):194-196. doi: 10.1016/j.ccell.2016.07.010. Cancer Cell. 2016. PMID: 27505669 Free PMC article.

4

Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2.

Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens PIH, Neel BG. Tsutsumi R, et al. Among authors: neel bg. Nat Commun. 2017 Sep 6;8(1):466. doi: 10.1038/s41467-017-00503-w. Nat Commun. 2017. PMID: 28878211 Free PMC article.

5

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.

Fedele C, Ran H, Diskin B, Wei W, Jen J, Geer MJ, Araki K, Ozerdem U, Simeone DM, Miller G, Neel BG, Tang KH. Fedele C, et al. Among authors: neel bg. Cancer Discov. 2018 Oct;8(10):1237-1249. doi: 10.1158/2159-8290.CD-18-0444. Epub 2018 Jul 25. Cancer Discov. 2018. PMID: 30045908 Free PMC article.

6

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma.

Zhang S, Dolgalev I, Zhang T, Ran H, Levine DA, Neel BG. Zhang S, et al. Among authors: neel bg. Nat Commun. 2019 Nov 26;10(1):5367. doi: 10.1038/s41467-019-13116-2. Nat Commun. 2019. PMID: 31772167 Free PMC article.

7

Corrigendum to: Off-target inhibition by active site-targeting SHP2 inhibitors.

Tsutsumi R, Ran H, Rademann J, Neel BG. Tsutsumi R, et al. Among authors: neel bg. FEBS Open Bio. 2019 Dec;9(12):2174. doi: 10.1002/2211-5463.12754. FEBS Open Bio. 2019. PMID: 31789461 Free PMC article. No abstract available.

8

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.

Fedele C, Li S, Teng KW, Foster CJR, Peng D, Ran H, Mita P, Geer MJ, Hattori T, Koide A, Wang Y, Tang KH, Leinwand J, Wang W, Diskin B, Deng J, Chen T, Dolgalev I, Ozerdem U, Miller G, Koide S, Wong KK, Neel BG. Fedele C, et al. Among authors: neel bg. J Exp Med. 2021 Jan 4;218(1):e20201414. doi: 10.1084/jem.20201414. J Exp Med. 2021. PMID: 33045063 Free PMC article.

9

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer.

Zhang S, Iyer S, Ran H, Dolgalev I, Gu S, Wei W, Foster CJR, Loomis CA, Olvera N, Dao F, Levine DA, Weinberg RA, Neel BG. Zhang S, et al. Among authors: neel bg. Cancer Discov. 2021 Feb;11(2):362-383. doi: 10.1158/2159-8290.CD-20-0455. Epub 2020 Nov 6. Cancer Discov. 2021. PMID: 33158842 Free PMC article.

10

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.

Zhang X, Dong Z, Zhang C, Ung CY, He S, Tao T, Oliveira AM, Meves A, Ji B, Look AT, Li H, Neel BG, Zhu S. Zhang X, et al. Among authors: neel bg. Cell Rep. 2017 Mar 21;18(12):2932-2942. doi: 10.1016/j.celrep.2017.02.065. Cell Rep. 2017. PMID: 28329685 Free PMC article.

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