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In-Cell Activation of Organo-Osmium(II) Anticancer Complexes.
Needham RJ, Sanchez-Cano C, Zhang X, Romero-Canelón I, Habtemariam A, Cooper MS, Meszaros L, Clarkson GJ, Blower PJ, Sadler PJ. Needham RJ, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1017-1020. doi: 10.1002/anie.201610290. Epub 2016 Dec 21. Angew Chem Int Ed Engl. 2017. PMID: 28000997 Free PMC article.
Photoactivated Osmium Arene Anticancer Complexes.
Xue X, Fu Y, He L, Salassa L, He LF, Hao YY, Koh MJ, Soulié C, Needham RJ, Habtemariam A, Garino C, Lomachenko KA, Su Z, Qian Y, Paterson MJ, Mao ZW, Liu HK, Sadler PJ. Xue X, et al. Among authors: needham rj. Inorg Chem. 2021 Dec 6;60(23):17450-17461. doi: 10.1021/acs.inorgchem.1c00241. Epub 2021 Sep 9. Inorg Chem. 2021. PMID: 34503331
Cu(III)-bis-thiolato complex forms an unusual mono-thiolato Cu(III)-peroxido adduct.
Donnelly JM , Lermyte F , Wolny JA , Walker M , Breeze BG , Needham RJ , Müller CS , O'Connor PB , Schünemann V , Collingwood JF , Sadler PJ . Donnelly JM , et al. Among authors: needham rj. Chem Commun (Camb). 2021 Jan 5;57(1):69-72. doi: 10.1039/d0cc06921c. Chem Commun (Camb). 2021. PMID: 33337460
Metallodrugs are unique: opportunities and challenges of discovery and development.
Anthony EJ, Bolitho EM, Bridgewater HE, Carter OWL, Donnelly JM, Imberti C, Lant EC, Lermyte F, Needham RJ, Palau M, Sadler PJ, Shi H, Wang FX, Zhang WY, Zhang Z. Anthony EJ, et al. Among authors: needham rj. Chem Sci. 2020 Nov 12;11(48):12888-12917. doi: 10.1039/d0sc04082g. Chem Sci. 2020. PMID: 34123239 Free PMC article. Review.
11 results