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Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D. Heybrock S, et al. Among authors: neculai d. Nat Commun. 2019 Aug 6;10(1):3521. doi: 10.1038/s41467-019-11425-0. Nat Commun. 2019. PMID: 31387993 Free PMC article.
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.
Lu Y, Zheng Y, Coyaud É, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught B, Sun Q, Neculai D. Lu Y, et al. Among authors: neculai d. Science. 2019 Oct 25;366(6464):460-467. doi: 10.1126/science.aau6391. Epub 2019 Oct 24. Science. 2019. PMID: 31649195
PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus.
Chen L, Tong Q, Chen X, Jiang P, Yu H, Zhao Q, Sun L, Liu C, Gu B, Zheng Y, Fei L, Jiang X, Li W, Volpe G, Abdul MM, Guo G, Zhang J, Qian P, Sun Q, Neculai D, Esteban MA, Li C, Wen F, Ji J. Chen L, et al. Among authors: neculai d. Nat Commun. 2021 May 14;12(1):2829. doi: 10.1038/s41467-021-22871-0. Nat Commun. 2021. PMID: 33990559 Free PMC article.
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Wang X, Jiang X, Li B, Zheng J, Guo J, Gao L, Du M, Weng X, Li L, Chen S, Zhang J, Fang L, Liu T, Wang L, Liu W, Neculai D, Sun Q. Wang X, et al. Among authors: neculai d. J Cell Biol. 2023 May 1;222(5):e202201068. doi: 10.1083/jcb.202201068. Epub 2023 Apr 12. J Cell Biol. 2023. PMID: 37043189 Free PMC article.
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.
Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S. Kook S, et al. Among authors: neculai d. J Biol Chem. 2016 Apr 15;291(16):8414-27. doi: 10.1074/jbc.M116.720201. Epub 2016 Feb 23. J Biol Chem. 2016. PMID: 26907692 Free PMC article.
Cholesterol Handling in Lysosomes and Beyond.
Meng Y, Heybrock S, Neculai D, Saftig P. Meng Y, et al. Among authors: neculai d. Trends Cell Biol. 2020 Jun;30(6):452-466. doi: 10.1016/j.tcb.2020.02.007. Epub 2020 Mar 23. Trends Cell Biol. 2020. PMID: 32413315 Review.
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders.
Wang A, Chen C, Mei C, Liu S, Xiang C, Fang W, Zhang F, Xu Y, Chen S, Zhang Q, Bai X, Lin A, Neculai D, Xia B, Ye C, Zou J, Liang T, Feng XH, Li X, Shen C, Xu P. Wang A, et al. Among authors: neculai d. Nat Cell Biol. 2024 Feb;26(2):219-234. doi: 10.1038/s41556-023-01339-x. Epub 2024 Jan 22. Nat Cell Biol. 2024. PMID: 38253667
53 results