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IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso AA, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F. Prelli Bozzo C, et al. Among authors: nchioua r. Nat Commun. 2021 Jul 28;12(1):4584. doi: 10.1038/s41467-021-24817-y. Nat Commun. 2021. PMID: 34321474 Free PMC article.
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ. Hayn M, et al. Among authors: nchioua r. Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27. Cell Rep. 2021. PMID: 33974846 Free PMC article.
Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and SARS-CoV-2 infection.
Schmidt H, Guthjahr L, Sauter A, Zech F, Nchioua R, Stenger S, Frick M, Kirchhoff F, Dietl P, Wittekindt OH. Schmidt H, et al. Among authors: nchioua r. Am J Physiol Cell Physiol. 2022 Apr 1;322(4):C591-C604. doi: 10.1152/ajpcell.00363.2021. Epub 2022 Feb 23. Am J Physiol Cell Physiol. 2022. PMID: 35196166 Free PMC article.
Actin cytoskeleton remodeling primes RIG-I-like receptor activation.
Acharya D, Reis R, Volcic M, Liu G, Wang MK, Chia BS, Nchioua R, Groß R, Münch J, Kirchhoff F, Sparrer KMJ, Gack MU. Acharya D, et al. Among authors: nchioua r. Cell. 2022 Sep 15;185(19):3588-3602.e21. doi: 10.1016/j.cell.2022.08.011. Cell. 2022. PMID: 36113429 Free PMC article.
Spike residue 403 affects binding of coronavirus spikes to human ACE2.
Zech F, Schniertshauer D, Jung C, Herrmann A, Cordsmeier A, Xie Q, Nchioua R, Prelli Bozzo C, Volcic M, Koepke L, Müller JA, Krüger J, Heller S, Stenger S, Hoffmann M, Pöhlmann S, Kleger A, Jacob T, Conzelmann KK, Ensser A, Sparrer KMJ, Kirchhoff F. Zech F, et al. Among authors: nchioua r. Nat Commun. 2021 Nov 25;12(1):6855. doi: 10.1038/s41467-021-27180-0. Nat Commun. 2021. PMID: 34824253 Free PMC article.
18 results