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Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
J Med Chem. 2023 Aug 24;66(16):11294-11323. doi: 10.1021/acs.jmedchem.3c00763. Epub 2023 Aug 15.
J Med Chem. 2023.
PMID: 37582241
Free PMC article.
Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE 3rd, Gangjee A, Matherly LH.
Dekhne AS, et al. Among authors: nayeen mj.
Mol Cancer Ther. 2019 Oct;18(10):1787-1799. doi: 10.1158/1535-7163.MCT-19-0037. Epub 2019 Jul 9.
Mol Cancer Ther. 2019.
PMID: 31289137
Free PMC article.
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Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Dekhne AS, Ning C, Nayeen MJ, Shah K, Kalpage H, Frühauf J, Wallace-Povirk A, O'Connor C, Hou Z, Kim S, Hüttemann M, Gangjee A, Matherly LH.
Dekhne AS, et al. Among authors: nayeen mj.
Mol Pharmacol. 2020 Jan;97(1):9-22. doi: 10.1124/mol.119.117937. Epub 2019 Nov 9.
Mol Pharmacol. 2020.
PMID: 31707355
Free PMC article.
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Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer.
Wallace-Povirk A, Hou Z, Nayeen MJ, Gangjee A, Matherly LH.
Wallace-Povirk A, et al. Among authors: nayeen mj.
Cancers (Basel). 2021 Dec 31;14(1):191. doi: 10.3390/cancers14010191.
Cancers (Basel). 2021.
PMID: 35008360
Free PMC article.
Review.
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Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE, Gangjee A, Matherly LH.
Dekhne AS, et al. Among authors: nayeen mj.
Mol Cancer Ther. 2023 Feb 1;22(2):287. doi: 10.1158/1535-7163.MCT-22-0766.
Mol Cancer Ther. 2023.
PMID: 36602953
No abstract available.
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Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Katinas JM, Nayeen MJ, Schneider M, Shah K, Fifer AN, Klapper LM, Sharma A, Thalluri K, Van Nieuwenhze MS, Hou Z, Gangjee A, Matherly LH, Dann CE 3rd.
Katinas JM, et al. Among authors: nayeen mj.
Biochemistry. 2024 Feb 7. doi: 10.1021/acs.biochem.3c00613. Online ahead of print.
Biochemistry. 2024.
PMID: 38324671
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Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer.
Wallace-Povirk A, O'Connor C, Dekhne AS, Bao X, Nayeen MJ, Schneider M, Katinas JM, Wong-Roushar J, Kim S, Polin L, Li J, Back JB, Dann CE, Gangjee A, Hou Z, Matherly LH.
Wallace-Povirk A, et al. Among authors: nayeen mj.
Mol Cancer Ther. 2024 Feb 20. doi: 10.1158/1535-7163.MCT-23-0550. Online ahead of print.
Mol Cancer Ther. 2024.
PMID: 38377173
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