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Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.
Nadal X, Del Río C, Casano S, Palomares B, Ferreiro-Vera C, Navarrete C, Sánchez-Carnerero C, Cantarero I, Bellido ML, Meyer S, Morello G, Appendino G, Muñoz E. Nadal X, et al. Among authors: navarrete c. Br J Pharmacol. 2017 Dec;174(23):4263-4276. doi: 10.1111/bph.14019. Epub 2017 Nov 2. Br J Pharmacol. 2017. PMID: 28853159 Free PMC article.
Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes.
Navarrete C, Sancho R, Caballero FJ, Pollastro F, Fiebich BL, Sterner O, Appendino G, Muñoz E. Navarrete C, et al. J Pharmacol Exp Ther. 2006 Oct;319(1):422-30. doi: 10.1124/jpet.106.108209. Epub 2006 Jul 13. J Pharmacol Exp Ther. 2006. PMID: 16840645
A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis.
Granja AG, Carrillo-Salinas F, Pagani A, Gómez-Cañas M, Negri R, Navarrete C, Mecha M, Mestre L, Fiebich BL, Cantarero I, Calzado MA, Bellido ML, Fernandez-Ruiz J, Appendino G, Guaza C, Muñoz E. Granja AG, et al. Among authors: navarrete c. J Neuroimmune Pharmacol. 2012 Dec;7(4):1002-16. doi: 10.1007/s11481-012-9399-3. Epub 2012 Sep 14. J Neuroimmune Pharmacol. 2012. PMID: 22971837
347 results