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An mpox virus mRNA-lipid nanoparticle vaccine confers protection against lethal orthopoxviral challenge.
Freyn AW, Atyeo C, Earl PL, Americo JL, Chuang GY, Natarajan H, Frey TR, Gall JG, Moliva JI, Hunegnaw R, Asthagiri Arunkumar G, Ogega CO, Nasir A, Santos G, Levin RH, Meni A, Jorquera PA, Bennett H, Johnson JA, Durney MA, Stewart-Jones G, Hooper JW, Colpitts TM, Alter G, Sullivan NJ, Carfi A, Moss B. Freyn AW, et al. Among authors: natarajan h. Sci Transl Med. 2023 Oct 4;15(716):eadg3540. doi: 10.1126/scitranslmed.adg3540. Epub 2023 Oct 4. Sci Transl Med. 2023. PMID: 37792954
Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis.
Bobak CA, Abhimanyu, Natarajan H, Gandhi T, Grimm SL, Nishiguchi T, Koster K, Longlax SC, Dlamini Q, Kahari J, Mtetwa G, Cirillo JD, O'Malley J, Hill JE, Coarfa C, DiNardo AR. Bobak CA, et al. Among authors: natarajan h. Aging (Albany NY). 2022 Mar 7;14(5):2174-2193. doi: 10.18632/aging.203936. Epub 2022 Mar 7. Aging (Albany NY). 2022. PMID: 35256539 Free PMC article.
Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV.
Ackerman ME, Das J, Pittala S, Broge T, Linde C, Suscovich TJ, Brown EP, Bradley T, Natarajan H, Lin S, Sassic JK, O'Keefe S, Mehta N, Goodman D, Sips M, Weiner JA, Tomaras GD, Haynes BF, Lauffenburger DA, Bailey-Kellogg C, Roederer M, Alter G. Ackerman ME, et al. Among authors: natarajan h. Nat Med. 2018 Oct;24(10):1590-1598. doi: 10.1038/s41591-018-0161-0. Epub 2018 Sep 3. Nat Med. 2018. PMID: 30177821 Free PMC article.
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination.
Suscovich TJ, Fallon JK, Das J, Demas AR, Crain J, Linde CH, Michell A, Natarajan H, Arevalo C, Broge T, Linnekin T, Kulkarni V, Lu R, Slein MD, Luedemann C, Marquette M, March S, Weiner J, Gregory S, Coccia M, Flores-Garcia Y, Zavala F, Ackerman ME, Bergmann-Leitner E, Hendriks J, Sadoff J, Dutta S, Bhatia SN, Lauffenburger DA, Jongert E, Wille-Reece U, Alter G. Suscovich TJ, et al. Among authors: natarajan h. Sci Transl Med. 2020 Jul 22;12(553):eabb4757. doi: 10.1126/scitranslmed.abb4757. Sci Transl Med. 2020. PMID: 32718991
Delayed fractional dosing with RTS,S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6- and Pf16-specific antibodies.
Das J, Fallon JK, Yu TC, Michell A, Suscovich TJ, Linde C, Natarajan H, Weiner J, Coccia M, Gregory S, Ackerman ME, Bergmann-Leitner E, Fontana L, Dutta S, Lauffenburger DA, Jongert E, Wille-Reece U, Alter G. Das J, et al. Among authors: natarajan h. Med. 2021 Nov 12;2(11):1269-1286.e9. doi: 10.1016/j.medj.2021.10.003. Med. 2021. PMID: 35590199 Free article. Clinical Trial.
Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice.
Brady JM, Phelps M, MacDonald SW, Lam EC, Nitido A, Parsons D, Boutros CL, Deal CE, Garcia-Beltran WF, Tanno S, Natarajan H, Ackerman ME, Vrbanac VD, Balazs AB. Brady JM, et al. Among authors: natarajan h. Sci Transl Med. 2022 Jul 27;14(655):eabn9662. doi: 10.1126/scitranslmed.abn9662. Epub 2022 Jul 27. Sci Transl Med. 2022. PMID: 35895834 Free PMC article.
SARS-CoV-2 mRNA vaccination elicits broad and potent Fc effector functions to VOCs in vulnerable populations.
Hederman AP, Natarajan H, Wiener JA, Wright PF, Bloch EM, Tobian AAR, Redd AD, Blankson JN, Rottenstreich A, Zarbiv G, Wolf D, Goetghebuer T, Marchant A, Ackerman ME. Hederman AP, et al. Among authors: natarajan h. medRxiv [Preprint]. 2022 Sep 18:2022.09.15.22280000. doi: 10.1101/2022.09.15.22280000. medRxiv. 2022. PMID: 36172122 Free PMC article. Updated. Preprint.
Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike.
Crowley AR, Natarajan H, Hederman AP, Bobak CA, Weiner JA, Wieland-Alter W, Lee J, Bloch EM, Tobian AAR, Redd AD, Blankson JN, Wolf D, Goetghebuer T, Marchant A, Connor RI, Wright PF, Ackerman ME. Crowley AR, et al. Among authors: natarajan h. Elife. 2022 Mar 15;11:e75228. doi: 10.7554/eLife.75228. Elife. 2022. PMID: 35289271 Free PMC article.
32 results