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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P, Pan R, Klumpp K, Aswad F, Rebo J, Narumiya S, Murakami M, Zuniga S, Sola I, Enjuanes L, Meyerholz DK, Fortney K, McCray PB Jr, Perlman S. Wong LR, et al. Among authors: narumiya s. Nature. 2022 May;605(7908):146-151. doi: 10.1038/s41586-022-04630-3. Epub 2022 Mar 21. Nature. 2022. PMID: 35314834 Free PMC article.
Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.
Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S. Vijay R, et al. Among authors: narumiya s. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5444-E5453. doi: 10.1073/pnas.1704099114. Epub 2017 Jun 19. Proc Natl Acad Sci U S A. 2017. PMID: 28630327 Free PMC article.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M. Taketomi Y, et al. Among authors: narumiya s. Nat Immunol. 2013 Jun;14(6):554-63. doi: 10.1038/ni.2586. Epub 2013 Apr 28. Nat Immunol. 2013. PMID: 23624557 Free PMC article.
618 results