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Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress.
Williamson LE, Reeder KM, Bailey K, Tran MH, Roy V, Fouch ME, Kose N, Trivette A, Nargi RS, Winkler ES, Kim AS, Gainza C, Rodriguez J, Armstrong E, Sutton RE, Reidy J, Carnahan RH, McDonald WH, Schoeder CT, Klimstra WB, Davidson E, Doranz BJ, Alter G, Meiler J, Schey KL, Julander JG, Diamond MS, Crowe JE Jr. Williamson LE, et al. Among authors: nargi rs. Cell. 2021 Aug 19;184(17):4430-4446.e22. doi: 10.1016/j.cell.2021.07.033. Cell. 2021. PMID: 34416147 Free PMC article.
Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.
Williamson LE, Gilliland T Jr, Yadav PK, Binshtein E, Bombardi R, Kose N, Nargi RS, Sutton RE, Durie CL, Armstrong E, Carnahan RH, Walker LM, Kim AS, Fox JM, Diamond MS, Ohi MD, Klimstra WB, Crowe JE Jr. Williamson LE, et al. Among authors: nargi rs. Cell. 2020 Dec 23;183(7):1884-1900.e23. doi: 10.1016/j.cell.2020.11.011. Epub 2020 Dec 9. Cell. 2020. PMID: 33301709 Free PMC article.
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein.
Suryadevara N, Shrihari S, Gilchuk P, VanBlargan LA, Binshtein E, Zost SJ, Nargi RS, Sutton RE, Winkler ES, Chen EC, Fouch ME, Davidson E, Doranz BJ, Chen RE, Shi PY, Carnahan RH, Thackray LB, Diamond MS, Crowe JE Jr. Suryadevara N, et al. Among authors: nargi rs. Cell. 2021 Apr 29;184(9):2316-2331.e15. doi: 10.1016/j.cell.2021.03.029. Epub 2021 Mar 16. Cell. 2021. PMID: 33773105 Free PMC article.
Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions.
Shiakolas AR, Kramer KJ, Wrapp D, Richardson SI, Schäfer A, Wall S, Wang N, Janowska K, Pilewski KA, Venkat R, Parks R, Manamela NP, Raju N, Fechter EF, Holt CM, Suryadevara N, Chen RE, Martinez DR, Nargi RS, Sutton RE, Ledgerwood JE, Graham BS, Diamond MS, Haynes BF, Acharya P, Carnahan RH, Crowe JE Jr, Baric RS, Morris L, McLellan JS, Georgiev IS. Shiakolas AR, et al. Among authors: nargi rs. Cell Rep Med. 2021 Jun 15;2(6):100313. doi: 10.1016/j.xcrm.2021.100313. Epub 2021 May 21. Cell Rep Med. 2021. PMID: 34056628 Free PMC article.
Pan-ebolavirus protective therapy by two multifunctional human antibodies.
Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe JE Jr. Gilchuk P, et al. Among authors: nargi rs. Cell. 2021 Oct 28;184(22):5593-5607.e18. doi: 10.1016/j.cell.2021.09.035. Cell. 2021. PMID: 34715022 Free PMC article.
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE Jr. Gilchuk P, et al. Immunity. 2020 Feb 18;52(2):388-403.e12. doi: 10.1016/j.immuni.2020.01.001. Epub 2020 Feb 4. Immunity. 2020. PMID: 32023489 Free PMC article.
Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics.
Gilchuk P, Bombardi RG, Erasmus JH, Tan Q, Nargi R, Soto C, Abbink P, Suscovich TJ, Durnell LA, Khandhar A, Archer J, Liang J, Fouch ME, Davidson E, Doranz BJ, Jones T, Larson E, Ertel S, Granger B, Fuerte-Stone J, Roy V, Broge T, Linnekin TC, Linde CH, Gorman MJ, Nkolola J, Alter G, Reed SG, Barouch DH, Diamond MS, Crowe JE Jr, Van Hoeven N, Thackray LB, Carnahan RH. Gilchuk P, et al. Nat Biomed Eng. 2020 Nov;4(11):1030-1043. doi: 10.1038/s41551-020-0594-x. Epub 2020 Aug 3. Nat Biomed Eng. 2020. PMID: 32747832 Free PMC article.
Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region.
Schoeder CT, Gilchuk P, Sangha AK, Ledwitch KV, Malherbe DC, Zhang X, Binshtein E, Williamson LE, Martina CE, Dong J, Armstrong E, Sutton R, Nargi R, Rodriguez J, Kuzmina N, Fiala B, King NP, Bukreyev A, Crowe JE Jr, Meiler J. Schoeder CT, et al. PLoS Pathog. 2022 May 18;18(5):e1010518. doi: 10.1371/journal.ppat.1010518. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35584193 Free PMC article.
31 results