Narczyk M - Search Results

1

The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site.

Bubić A, Narczyk M, Petek A, Wojtyś MI, Maksymiuk W, Wielgus-Kutrowska B, Winiewska-Szajewska M, Pavkov-Keller T, Bertoša B, Štefanić Z, Luić M, Bzowska A, Leščić Ašler I. Bubić A, et al. Among authors: narczyk m. Int J Biol Macromol. 2023 Jan 31;226:37-50. doi: 10.1016/j.ijbiomac.2022.12.001. Epub 2022 Dec 5. Int J Biol Macromol. 2023. PMID: 36470440 Free article.

2

New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A.

Štefanić Z, Narczyk M, Mikleušević G, Wielgus-Kutrowska B, Bzowska A, Luić M. Štefanić Z, et al. Among authors: narczyk m. FEBS Lett. 2012 Apr 5;586(7):967-71. doi: 10.1016/j.febslet.2012.02.039. Epub 2012 Mar 1. FEBS Lett. 2012. PMID: 22569248 Free article.

3

New Insights into Active Site Conformation Dynamics of E. coli PNP Revealed by Combined H/D Exchange Approach and Molecular Dynamics Simulations.

Kazazić S, Bertoša B, Luić M, Mikleušević G, Tarnowski K, Dadlez M, Narczyk M, Bzowska A. Kazazić S, et al. Among authors: narczyk m. J Am Soc Mass Spectrom. 2016 Jan;27(1):73-82. doi: 10.1007/s13361-015-1239-2. Epub 2015 Sep 3. J Am Soc Mass Spectrom. 2016. PMID: 26337516

4

Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features.

Narczyk M, Bertoša B, Papa L, Vuković V, Leščić Ašler I, Wielgus-Kutrowska B, Bzowska A, Luić M, Štefanić Z. Narczyk M, et al. FEBS J. 2018 Apr;285(7):1305-1325. doi: 10.1111/febs.14403. Epub 2018 Feb 26. FEBS J. 2018. PMID: 29430816 Free article.

5

Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis.

Štefanić Z, Narczyk M, Mikleušević G, Kazazić S, Bzowska A, Luić M. Štefanić Z, et al. Among authors: narczyk m. Sci Rep. 2018 Oct 18;8(1):15427. doi: 10.1038/s41598-018-33723-1. Sci Rep. 2018. PMID: 30337572 Free PMC article.

6

Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium.

Narczyk M, Wojtyś MI, Leščić Ašler I, Žinić B, Luić M, Jagusztyn-Krynicka EK, Štefanić Z, Bzowska A. Narczyk M, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1083-1097. doi: 10.1080/14756366.2022.2061965. J Enzyme Inhib Med Chem. 2022. PMID: 35437103 Free PMC article.

7

Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.

Mikleušević G, Stefanić Z, Narczyk M, Wielgus-Kutrowska B, Bzowska A, Luić M. Mikleušević G, et al. Among authors: narczyk m. Biochimie. 2011 Sep;93(9):1610-22. doi: 10.1016/j.biochi.2011.05.030. Epub 2011 Jun 13. Biochimie. 2011. PMID: 21672603

8

Homooligomerization is needed for stability: a molecular modelling and solution study of Escherichia coli purine nucleoside phosphorylase.

Bertoša B, Mikleušević G, Wielgus-Kutrowska B, Narczyk M, Hajnić M, Leščić Ašler I, Tomić S, Luić M, Bzowska A. Bertoša B, et al. Among authors: narczyk m. FEBS J. 2014 Apr;281(7):1860-71. doi: 10.1111/febs.12746. FEBS J. 2014. PMID: 24785777 Free article.

9

Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent.

Narczyk M, Mioduszewski Ł, Oksiejuk A, Winiewska-Szajewska M, Wielgus-Kutrowska B, Gojdź A, Cieśla J, Bzowska A. Narczyk M, et al. Sci Rep. 2021 May 27;11(1):11144. doi: 10.1038/s41598-021-90472-4. Sci Rep. 2021. PMID: 34045551 Free PMC article.

10

1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.

Chojnowski G, Breer K, Narczyk M, Wielgus-Kutrowska B, Czapinska H, Hashimoto M, Hikishima S, Yokomatsu T, Bochtler M, Girstun A, Staroń K, Bzowska A. Chojnowski G, et al. Among authors: narczyk m. Biochem Biophys Res Commun. 2010 Jan 1;391(1):703-8. doi: 10.1016/j.bbrc.2009.11.124. Epub 2009 Nov 26. Biochem Biophys Res Commun. 2010. PMID: 19944078

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