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Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo.
Jayaraman M, Ansell SM, Mui BL, Tam YK, Chen J, Du X, Butler D, Eltepu L, Matsuda S, Narayanannair JK, Rajeev KG, Hafez IM, Akinc A, Maier MA, Tracy MA, Cullis PR, Madden TD, Manoharan M, Hope MJ. Jayaraman M, et al. Among authors: narayanannair jk. Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8529-33. doi: 10.1002/anie.201203263. Epub 2012 Jul 10. Angew Chem Int Ed Engl. 2012. PMID: 22782619 Free PMC article.
Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles.
Mui BL, Tam YK, Jayaraman M, Ansell SM, Du X, Tam YY, Lin PJ, Chen S, Narayanannair JK, Rajeev KG, Manoharan M, Akinc A, Maier MA, Cullis P, Madden TD, Hope MJ. Mui BL, et al. Among authors: narayanannair jk. Mol Ther Nucleic Acids. 2013 Dec 17;2(12):e139. doi: 10.1038/mtna.2013.66. Mol Ther Nucleic Acids. 2013. PMID: 24345865 Free PMC article.
Branched multifunctional polyether polyketals: variation of ketal group structure enables unprecedented control over polymer degradation in solution and within cells.
Shenoi RA, Narayanannair JK, Hamilton JL, Lai BF, Horte S, Kainthan RK, Varghese JP, Rajeev KG, Manoharan M, Kizhakkedathu JN. Shenoi RA, et al. Among authors: narayanannair jk. J Am Chem Soc. 2012 Sep 12;134(36):14945-57. doi: 10.1021/ja305080f. Epub 2012 Aug 30. J Am Chem Soc. 2012. PMID: 22906064