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Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19.
Zumbrun EE, Kaku CI, Dillinger L, Zak SE, Kuehne AI, Bakken RR, Koehler JW, Delp KL, Stefan CP, Kumar R, Kugelman JR, Moreau AM, Zeng X, Dye JM, Herbert AS, Narayan K, Walker LM. Zumbrun EE, et al. Among authors: narayan k. Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0135322. doi: 10.1128/aac.01353-22. Epub 2022 Dec 15. Antimicrob Agents Chemother. 2023. PMID: 36519929 Free PMC article.
Antibody-mediated protection against symptomatic COVID-19 can be achieved at low serum neutralizing titers.
Schmidt P, Narayan K, Li Y, Kaku CI, Brown ME, Champney E, Geoghegan JC, Vásquez M, Krauland EM, Yockachonis T, Bai S, Gunn BM, Cammarata A, Rubino CM, Ambrose P, Walker LM. Schmidt P, et al. Among authors: narayan k. Sci Transl Med. 2023 Mar 22;15(688):eadg2783. doi: 10.1126/scitranslmed.adg2783. Epub 2023 Mar 22. Sci Transl Med. 2023. PMID: 36947596 Free article.
Prevention of COVID-19 Following a Single Intramuscular Administration of Adintrevimab: Results From a Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Trial (EVADE).
Ison MG, Weinstein DF, Dobryanska M, Holmes A, Phelan AM, Li Y, Gupta D, Narayan K, Tosh K, Hershberger E, Connolly LE, Yalcin I, Campanaro E, Hawn P, Schmidt P; EVADE Study Group. Ison MG, et al. Among authors: narayan k. Open Forum Infect Dis. 2023 Jun 13;10(7):ofad314. doi: 10.1093/ofid/ofad314. eCollection 2023 Jul. Open Forum Infect Dis. 2023. PMID: 37496612 Free PMC article.
Safety, Pharmacokinetics, Serum Neutralizing Titers, and Immunogenicity of Adintrevimab, a Monoclonal Antibody Targeting SARS-CoV-2: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Dose-escalation Study in Healthy Adults.
Schmidt P, Gong J, Narayan K, Gupta D, Engler F, Li Y, Copans A, Campanaro E. Schmidt P, et al. Among authors: narayan k. Infect Dis Ther. 2023 May;12(5):1365-1377. doi: 10.1007/s40121-023-00794-1. Epub 2023 Apr 25. Infect Dis Ther. 2023. PMID: 37185797 Free PMC article.
Efficacy and Safety of Adintrevimab (ADG20) for the Treatment of High-Risk Ambulatory Patients With Mild or Moderate Coronavirus Disease 2019: Results From a Phase 2/3, Randomized, Placebo-Controlled Trial (STAMP) Conducted During Delta Predominance and Early Emergence of Omicron.
Ison MG, Popejoy M, Evgeniev N, Tzekova M, Mahoney K, Betancourt N, Li Y, Gupta D, Narayan K, Hershberger E, Connolly LE, Yalcin I, Das AF, Genge J, Smith M, Campanaro E, Hawn P, Schmidt P; STAMP Study Group. Ison MG, et al. Among authors: narayan k. Open Forum Infect Dis. 2023 May 24;10(6):ofad279. doi: 10.1093/ofid/ofad279. eCollection 2023 Jun. Open Forum Infect Dis. 2023. PMID: 37351456 Free PMC article.
Extending human IgG half-life using structure-guided design.
Booth BJ, Ramakrishnan B, Narayan K, Wollacott AM, Babcock GJ, Shriver Z, Viswanathan K. Booth BJ, et al. Among authors: narayan k. MAbs. 2018 Oct;10(7):1098-1110. doi: 10.1080/19420862.2018.1490119. Epub 2018 Jul 26. MAbs. 2018. PMID: 29947573 Free PMC article.
Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study.
Hershberger E, Sloan S, Narayan K, Hay CA, Smith P, Engler F, Jeeninga R, Smits S, Trevejo J, Shriver Z, Oldach D. Hershberger E, et al. Among authors: narayan k. EBioMedicine. 2019 Feb;40:574-582. doi: 10.1016/j.ebiom.2018.12.051. Epub 2019 Jan 9. EBioMedicine. 2019. PMID: 30638863 Free PMC article. Clinical Trial.
1,053 results