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Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway.
Jakóbkiewicz-Banecka J, Piotrowska E, Narajczyk M, Barańska S, Wegrzyn G. Jakóbkiewicz-Banecka J, et al. Among authors: narajczyk m. J Biomed Sci. 2009 Mar 2;16(1):26. doi: 10.1186/1423-0127-16-26. J Biomed Sci. 2009. PMID: 19272193 Free PMC article.
Genistein: a natural isoflavone with a potential for treatment of genetic diseases.
Wegrzyn G, Jakóbkiewicz-Banecka J, Gabig-Cimińska M, Piotrowska E, Narajczyk M, Kloska A, Malinowska M, Dziedzic D, Gołebiewska I, Moskot M, Wegrzyn A. Wegrzyn G, et al. Among authors: narajczyk m. Biochem Soc Trans. 2010 Apr;38(2):695-701. doi: 10.1042/BST0380695. Biochem Soc Trans. 2010. PMID: 20298245 Review.
Substrate reduction therapies for mucopolysaccharidoses.
Jakóbkiewicz-Banecka J, Piotrowska E, Gabig-Cimińska M, Borysiewicz E, Słomińska-Wojewódzka M, Narajczyk M, Węgrzyn A, Węgrzyn G. Jakóbkiewicz-Banecka J, et al. Among authors: narajczyk m. Curr Pharm Biotechnol. 2011 Nov;12(11):1860-5. doi: 10.2174/138920111798376932. Curr Pharm Biotechnol. 2011. PMID: 21902626 Review.
Synthetic genistein derivatives as modulators of glycosaminoglycan storage.
Kloska A, Narajczyk M, Jakóbkiewicz-Banecka J, Grynkiewicz G, Szeja W, Gabig-Cimińska M, Węgrzyn G. Kloska A, et al. Among authors: narajczyk m. J Transl Med. 2012 Jul 30;10:153. doi: 10.1186/1479-5876-10-153. J Transl Med. 2012. PMID: 22846663 Free PMC article.
51 results