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Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.
Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G. Hollenhorst MI, et al. Among authors: nandigama r. J Clin Invest. 2022 Jul 1;132(13):e150951. doi: 10.1172/JCI150951. J Clin Invest. 2022. PMID: 35503420 Free PMC article.
Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.
Hollenhorst MI, Jurastow I, Nandigama R, Appenzeller S, Li L, Vogel J, Wiederhold S, Althaus M, Empting M, Altmüller J, Hirsch AKH, Flockerzi V, Canning BJ, Saliba AE, Krasteva-Christ G. Hollenhorst MI, et al. Among authors: nandigama r. FASEB J. 2020 Jan;34(1):316-332. doi: 10.1096/fj.201901314RR. Epub 2019 Nov 22. FASEB J. 2020. PMID: 31914675
LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy.
Rossow L, Veitl S, Vorlová S, Wax JK, Kuhn AE, Maltzahn V, Upcin B, Karl F, Hoffmann H, Gätzner S, Kallius M, Nandigama R, Scheld D, Irmak S, Herterich S, Zernecke A, Ergün S, Henke E. Rossow L, et al. Among authors: nandigama r. Oncogene. 2018 Sep;37(36):4921-4940. doi: 10.1038/s41388-018-0320-2. Epub 2018 May 21. Oncogene. 2018. PMID: 29780168 Free PMC article.
Restriction of drug transport by the tumor environment.
Nandigama R, Upcin B, Aktas BH, Ergün S, Henke E. Nandigama R, et al. Histochem Cell Biol. 2018 Dec;150(6):631-648. doi: 10.1007/s00418-018-1744-z. Epub 2018 Oct 25. Histochem Cell Biol. 2018. PMID: 30361778 Review.
22 results